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MICMIC: identification of DNA methylation of distal regulatory regions with causal effects on tumorigenesis

Aberrant promoter methylation is a common mechanism for tumor suppressor inactivation in cancer. We develop a set of tools to identify genome-wide DNA methylation in distal regions with causal effect on tumorigenesis called MICMIC. Many predictions are directly validated by dCas9-based epigenetic ed...

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Detalles Bibliográficos
Autores principales:	Tong, Yin, Sun, Jianlong, Wong, Chi Fat, Kang, Qingzheng, Ru, Beibei, Wong, Ching Ngar, Chan, April Sheila, Leung, Suet Yi, Zhang, Jiangwen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Method
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989391/ https://www.ncbi.nlm.nih.gov/pubmed/29871649 http://dx.doi.org/10.1186/s13059-018-1442-0

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