Safety and efficacy of human embryonic stem cell-derived astrocytes following intrathecal transplantation in SOD1(G93A) and NSG animal models

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a motor neuron (MN) disease characterized by the loss of MNs in the central nervous system. As MNs die, patients progressively lose their ability to control voluntary movements, become paralyzed and eventually die from respiratory/deglutition failur...

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Detalles Bibliográficos
Autores principales: Izrael, Michal, Slutsky, Shalom Guy, Admoni, Tamar, Cohen, Louisa, Granit, Avital, Hasson, Arik, Itskovitz-Eldor, Joseph, Krush Paker, Lena, Kuperstein, Graciela, Lavon, Neta, Yehezkel Ionescu, Shiran, Solmesky, Leonardo Javier, Zaguri, Rachel, Zhuravlev, Alina, Volman, Ella, Chebath, Judith, Revel, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989413/
https://www.ncbi.nlm.nih.gov/pubmed/29871694
http://dx.doi.org/10.1186/s13287-018-0890-5

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