Reasons and predictors for antiretroviral therapy change among HIV-infected adults at South West Ethiopia

OBJECTIVE: This retrospective cohort study is aimed to assess reasons and predictors of regimen change from initial highly active antiretroviral therapy among 1533 Human Immunodeficiency virus-infected adult patients at the Jimma University Tertiary Hospital. RESULTS: One in two (47.7%) adults chang...

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Autores principales: Mekonnen, Endalkachew, Workicho, Abdulhalik, Hussein, Nezif, Feyera, Teka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989425/
https://www.ncbi.nlm.nih.gov/pubmed/29871671
http://dx.doi.org/10.1186/s13104-018-3470-y
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author Mekonnen, Endalkachew
Workicho, Abdulhalik
Hussein, Nezif
Feyera, Teka
author_facet Mekonnen, Endalkachew
Workicho, Abdulhalik
Hussein, Nezif
Feyera, Teka
author_sort Mekonnen, Endalkachew
collection PubMed
description OBJECTIVE: This retrospective cohort study is aimed to assess reasons and predictors of regimen change from initial highly active antiretroviral therapy among 1533 Human Immunodeficiency virus-infected adult patients at the Jimma University Tertiary Hospital. RESULTS: One in two (47.7%) adults changed their antiretroviral therapy regimen. Patients who were above the primary level of education [Hazard ratio (HR) 1.241 (95% CI 1.070–1.440)] and with human immunodeficiency virus/tuberculosis co-infection [HR 1.405 (95% CI 1.156–1.708)] had the higher risk of regimen change than their comparator. Individuals on Efavirenz [HR 0.675 (95% CI 0.553–0.825)] and non-stavudine [HR 0.494 (95% CI 0.406–0.601)] based regimens had lower risk of regimen change.
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spelling pubmed-59894252018-06-20 Reasons and predictors for antiretroviral therapy change among HIV-infected adults at South West Ethiopia Mekonnen, Endalkachew Workicho, Abdulhalik Hussein, Nezif Feyera, Teka BMC Res Notes Research Note OBJECTIVE: This retrospective cohort study is aimed to assess reasons and predictors of regimen change from initial highly active antiretroviral therapy among 1533 Human Immunodeficiency virus-infected adult patients at the Jimma University Tertiary Hospital. RESULTS: One in two (47.7%) adults changed their antiretroviral therapy regimen. Patients who were above the primary level of education [Hazard ratio (HR) 1.241 (95% CI 1.070–1.440)] and with human immunodeficiency virus/tuberculosis co-infection [HR 1.405 (95% CI 1.156–1.708)] had the higher risk of regimen change than their comparator. Individuals on Efavirenz [HR 0.675 (95% CI 0.553–0.825)] and non-stavudine [HR 0.494 (95% CI 0.406–0.601)] based regimens had lower risk of regimen change. BioMed Central 2018-06-05 /pmc/articles/PMC5989425/ /pubmed/29871671 http://dx.doi.org/10.1186/s13104-018-3470-y Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Note
Mekonnen, Endalkachew
Workicho, Abdulhalik
Hussein, Nezif
Feyera, Teka
Reasons and predictors for antiretroviral therapy change among HIV-infected adults at South West Ethiopia
title Reasons and predictors for antiretroviral therapy change among HIV-infected adults at South West Ethiopia
title_full Reasons and predictors for antiretroviral therapy change among HIV-infected adults at South West Ethiopia
title_fullStr Reasons and predictors for antiretroviral therapy change among HIV-infected adults at South West Ethiopia
title_full_unstemmed Reasons and predictors for antiretroviral therapy change among HIV-infected adults at South West Ethiopia
title_short Reasons and predictors for antiretroviral therapy change among HIV-infected adults at South West Ethiopia
title_sort reasons and predictors for antiretroviral therapy change among hiv-infected adults at south west ethiopia
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989425/
https://www.ncbi.nlm.nih.gov/pubmed/29871671
http://dx.doi.org/10.1186/s13104-018-3470-y
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