Performance evaluation of three rapid screening assays for detection of antibodies to hepatitis C virus in Cameroon

OBJECTIVE: This study was aimed at evaluating the performance of three CE-marked rapid diagnostic tests (RDTs): Multisure-HCV, First Response(®) and Toyo(®); for screening anti- HCV antibody using plasma samples. RESULTS: Overall, 200 plasma samples were used. Sensibility and specificity of these RD...

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Autores principales: Fondjo, Clavel Landry Kouam, Ngoupo, Paul Alain Tagnouokam, Ngono, Laure, Plantier, Jean-Christophe, Njouom, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989429/
https://www.ncbi.nlm.nih.gov/pubmed/29871688
http://dx.doi.org/10.1186/s13104-018-3465-8
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author Fondjo, Clavel Landry Kouam
Ngoupo, Paul Alain Tagnouokam
Ngono, Laure
Plantier, Jean-Christophe
Njouom, Richard
author_facet Fondjo, Clavel Landry Kouam
Ngoupo, Paul Alain Tagnouokam
Ngono, Laure
Plantier, Jean-Christophe
Njouom, Richard
author_sort Fondjo, Clavel Landry Kouam
collection PubMed
description OBJECTIVE: This study was aimed at evaluating the performance of three CE-marked rapid diagnostic tests (RDTs): Multisure-HCV, First Response(®) and Toyo(®); for screening anti- HCV antibody using plasma samples. RESULTS: Overall, 200 plasma samples were used. Sensibility and specificity of these RDTs range from 71 to 99 and 78 to 100% respectively. Multisure scored a sensitivity at 99% (95% CI 97–100%) and First Response reached a specificity at 90% (95% CI 85–94.9%). Further studies should be conducted to establish an algorithm using these RTDs for the detection of HCV infection in Cameroon.
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spelling pubmed-59894292018-06-21 Performance evaluation of three rapid screening assays for detection of antibodies to hepatitis C virus in Cameroon Fondjo, Clavel Landry Kouam Ngoupo, Paul Alain Tagnouokam Ngono, Laure Plantier, Jean-Christophe Njouom, Richard BMC Res Notes Research Note OBJECTIVE: This study was aimed at evaluating the performance of three CE-marked rapid diagnostic tests (RDTs): Multisure-HCV, First Response(®) and Toyo(®); for screening anti- HCV antibody using plasma samples. RESULTS: Overall, 200 plasma samples were used. Sensibility and specificity of these RDTs range from 71 to 99 and 78 to 100% respectively. Multisure scored a sensitivity at 99% (95% CI 97–100%) and First Response reached a specificity at 90% (95% CI 85–94.9%). Further studies should be conducted to establish an algorithm using these RTDs for the detection of HCV infection in Cameroon. BioMed Central 2018-06-05 /pmc/articles/PMC5989429/ /pubmed/29871688 http://dx.doi.org/10.1186/s13104-018-3465-8 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Note
Fondjo, Clavel Landry Kouam
Ngoupo, Paul Alain Tagnouokam
Ngono, Laure
Plantier, Jean-Christophe
Njouom, Richard
Performance evaluation of three rapid screening assays for detection of antibodies to hepatitis C virus in Cameroon
title Performance evaluation of three rapid screening assays for detection of antibodies to hepatitis C virus in Cameroon
title_full Performance evaluation of three rapid screening assays for detection of antibodies to hepatitis C virus in Cameroon
title_fullStr Performance evaluation of three rapid screening assays for detection of antibodies to hepatitis C virus in Cameroon
title_full_unstemmed Performance evaluation of three rapid screening assays for detection of antibodies to hepatitis C virus in Cameroon
title_short Performance evaluation of three rapid screening assays for detection of antibodies to hepatitis C virus in Cameroon
title_sort performance evaluation of three rapid screening assays for detection of antibodies to hepatitis c virus in cameroon
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989429/
https://www.ncbi.nlm.nih.gov/pubmed/29871688
http://dx.doi.org/10.1186/s13104-018-3465-8
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