Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types

BACKGROUND: Single-cell genomic methods now provide unprecedented resolution for characterizing the component cell types and states of tissues such as the epithelial subsets of the gastrointestinal tract. Nevertheless, functional studies of these subsets at scale require faithful in vitro models of...

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Detalles Bibliográficos
Autores principales: Mead, Benjamin E., Ordovas-Montanes, Jose, Braun, Alexandra P., Levy, Lauren E., Bhargava, Prerna, Szucs, Matthew J., Ammendolia, Dustin A., MacMullan, Melanie A., Yin, Xiaolei, Hughes, Travis K., Wadsworth, Marc H., Ahmad, Rushdy, Rakoff-Nahoum, Seth, Carr, Steven A., Langer, Robert, Collins, James J., Shalek, Alex K., Karp, Jeffrey M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989470/
https://www.ncbi.nlm.nih.gov/pubmed/29871632
http://dx.doi.org/10.1186/s12915-018-0527-2

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