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Factors predicting response of pseudophakic cystoid macular edema to topical steroids and nepafenac
PURPOSE: The purpose of this study is to determine factors predicting resolution of acute pseudophakic cystoid macular edema (PCME) after 6 weeks of topical prednisolone and nepafenac application. METHODS: Case records of patients with a clinical and optical coherence tomography (OCT)-based diagnosi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989507/ https://www.ncbi.nlm.nih.gov/pubmed/29785993 http://dx.doi.org/10.4103/ijo.IJO_735_17 |
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author | Sengupta, Sabyasachi Vasavada, Dhaivat Pan, Utsab Sindal, Manavi |
author_facet | Sengupta, Sabyasachi Vasavada, Dhaivat Pan, Utsab Sindal, Manavi |
author_sort | Sengupta, Sabyasachi |
collection | PubMed |
description | PURPOSE: The purpose of this study is to determine factors predicting resolution of acute pseudophakic cystoid macular edema (PCME) after 6 weeks of topical prednisolone and nepafenac application. METHODS: Case records of patients with a clinical and optical coherence tomography (OCT)-based diagnosis of acute PCME were retrospectively reviewed for best-corrected visual acuity and OCT-based parameters at the time of presentation with PCME. In addition, demographic variables, intraoperative and early postoperative factors, and type of treatment prescribed (tapering vs. nontapering prednisolone, generic vs. branded prednisolone and nepafenac) were recorded from case records for analysis. Complete and any successes were defined and baseline factors predicting complete success at 6 weeks were analyzed. RESULTS: We analyzed 69 eyes of 69 patients out of which complete success with topical medications was seen in 37 eyes (54%) and any success was seen in 55 eyes (80%) at 6 weeks. Multivariable logistic regression showed that eyes with lower vision at presentation had a significantly lower likelihood of experiencing both, complete (odds ratio [OR] = 0.83 with one-line decrement in baseline vision, 95% confidence interval [CI] = 0.61–0.89, P = 0.003) and any success (OR = 0.61, 95% CI = 0.4–0.9, P = 0.007). Baseline OCT thickness did not influence success rates. CONCLUSION: Topical prednisolone and nepafenac lead to resolution in PCME in half of the eyes at 6 weeks. Baseline vision is the only factor predicting rates of success and PCME resolution with topical medications. |
format | Online Article Text |
id | pubmed-5989507 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59895072018-06-15 Factors predicting response of pseudophakic cystoid macular edema to topical steroids and nepafenac Sengupta, Sabyasachi Vasavada, Dhaivat Pan, Utsab Sindal, Manavi Indian J Ophthalmol Original Article PURPOSE: The purpose of this study is to determine factors predicting resolution of acute pseudophakic cystoid macular edema (PCME) after 6 weeks of topical prednisolone and nepafenac application. METHODS: Case records of patients with a clinical and optical coherence tomography (OCT)-based diagnosis of acute PCME were retrospectively reviewed for best-corrected visual acuity and OCT-based parameters at the time of presentation with PCME. In addition, demographic variables, intraoperative and early postoperative factors, and type of treatment prescribed (tapering vs. nontapering prednisolone, generic vs. branded prednisolone and nepafenac) were recorded from case records for analysis. Complete and any successes were defined and baseline factors predicting complete success at 6 weeks were analyzed. RESULTS: We analyzed 69 eyes of 69 patients out of which complete success with topical medications was seen in 37 eyes (54%) and any success was seen in 55 eyes (80%) at 6 weeks. Multivariable logistic regression showed that eyes with lower vision at presentation had a significantly lower likelihood of experiencing both, complete (odds ratio [OR] = 0.83 with one-line decrement in baseline vision, 95% confidence interval [CI] = 0.61–0.89, P = 0.003) and any success (OR = 0.61, 95% CI = 0.4–0.9, P = 0.007). Baseline OCT thickness did not influence success rates. CONCLUSION: Topical prednisolone and nepafenac lead to resolution in PCME in half of the eyes at 6 weeks. Baseline vision is the only factor predicting rates of success and PCME resolution with topical medications. Medknow Publications & Media Pvt Ltd 2018-06 /pmc/articles/PMC5989507/ /pubmed/29785993 http://dx.doi.org/10.4103/ijo.IJO_735_17 Text en Copyright: © 2018 Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Sengupta, Sabyasachi Vasavada, Dhaivat Pan, Utsab Sindal, Manavi Factors predicting response of pseudophakic cystoid macular edema to topical steroids and nepafenac |
title | Factors predicting response of pseudophakic cystoid macular edema to topical steroids and nepafenac |
title_full | Factors predicting response of pseudophakic cystoid macular edema to topical steroids and nepafenac |
title_fullStr | Factors predicting response of pseudophakic cystoid macular edema to topical steroids and nepafenac |
title_full_unstemmed | Factors predicting response of pseudophakic cystoid macular edema to topical steroids and nepafenac |
title_short | Factors predicting response of pseudophakic cystoid macular edema to topical steroids and nepafenac |
title_sort | factors predicting response of pseudophakic cystoid macular edema to topical steroids and nepafenac |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989507/ https://www.ncbi.nlm.nih.gov/pubmed/29785993 http://dx.doi.org/10.4103/ijo.IJO_735_17 |
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