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Comparison of optical coherence tomography angiography and fundus fluorescein angiography features of retinal capillary hemangioblastoma

The aim of this study is to compare the optical coherence tomography angiography (OCTA) and fundus fluorescein angiography (FFA) features of retinal capillary hemangioblastoma (RCH). This is an observational case series of three patients with von Hippel–Lindau (VHL) disease and one patient with juxt...

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Autores principales: Sagar, Pradeep, Rajesh, R, Shanmugam, Mahesh, Konana, Vinaya Kumar, Mishra, Divyansh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989523/
https://www.ncbi.nlm.nih.gov/pubmed/29786009
http://dx.doi.org/10.4103/ijo.IJO_1199_17
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author Sagar, Pradeep
Rajesh, R
Shanmugam, Mahesh
Konana, Vinaya Kumar
Mishra, Divyansh
author_facet Sagar, Pradeep
Rajesh, R
Shanmugam, Mahesh
Konana, Vinaya Kumar
Mishra, Divyansh
author_sort Sagar, Pradeep
collection PubMed
description The aim of this study is to compare the optical coherence tomography angiography (OCTA) and fundus fluorescein angiography (FFA) features of retinal capillary hemangioblastoma (RCH). This is an observational case series of three patients with von Hippel–Lindau (VHL) disease and one patient with juxtapapillary RCH. All patients underwent FFA with a mydriatic fundus camera and OCTA with swept-source angio OCT. The FFA and OCTA characteristics of tumors were compared. In our series, FFA could identify tumors as small as the width of a third-order retinal artery, which was missed on clinical examination. OCTA identified these tiny tumors, but only those closer to the posterior pole. Both FFA and OCTA could identify the intrinsic vasculature and feeder vessel in juxtapapillary RCH. On OCTA, the tumors were better defined than in FFA. The depth of the lesion can be identified on OCTA. Feeder and the draining vessels could be identified precisely in OCTA than FFA, particularly in small tumors. OCTA can identify tumors in VHL missed on clinical examination. It can identify the feeder vessel and intrinsic vasculature of sessile juxtapapillary RCH and aids in its diagnosis. Tumors are better defined in OCTA than FFA due to the absence of leakage. However, FFA can identify nearly all the early tumors, but OCTA fails to image the peripheral tumors due to its smaller field and prolonged acquisition time. Technological advances and the development of wide-field OCTA in the future can be helpful in identifying all the unsuspected tumors in VHL disease.
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spelling pubmed-59895232018-06-15 Comparison of optical coherence tomography angiography and fundus fluorescein angiography features of retinal capillary hemangioblastoma Sagar, Pradeep Rajesh, R Shanmugam, Mahesh Konana, Vinaya Kumar Mishra, Divyansh Indian J Ophthalmol Case Report The aim of this study is to compare the optical coherence tomography angiography (OCTA) and fundus fluorescein angiography (FFA) features of retinal capillary hemangioblastoma (RCH). This is an observational case series of three patients with von Hippel–Lindau (VHL) disease and one patient with juxtapapillary RCH. All patients underwent FFA with a mydriatic fundus camera and OCTA with swept-source angio OCT. The FFA and OCTA characteristics of tumors were compared. In our series, FFA could identify tumors as small as the width of a third-order retinal artery, which was missed on clinical examination. OCTA identified these tiny tumors, but only those closer to the posterior pole. Both FFA and OCTA could identify the intrinsic vasculature and feeder vessel in juxtapapillary RCH. On OCTA, the tumors were better defined than in FFA. The depth of the lesion can be identified on OCTA. Feeder and the draining vessels could be identified precisely in OCTA than FFA, particularly in small tumors. OCTA can identify tumors in VHL missed on clinical examination. It can identify the feeder vessel and intrinsic vasculature of sessile juxtapapillary RCH and aids in its diagnosis. Tumors are better defined in OCTA than FFA due to the absence of leakage. However, FFA can identify nearly all the early tumors, but OCTA fails to image the peripheral tumors due to its smaller field and prolonged acquisition time. Technological advances and the development of wide-field OCTA in the future can be helpful in identifying all the unsuspected tumors in VHL disease. Medknow Publications & Media Pvt Ltd 2018-06 /pmc/articles/PMC5989523/ /pubmed/29786009 http://dx.doi.org/10.4103/ijo.IJO_1199_17 Text en Copyright: © 2018 Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Sagar, Pradeep
Rajesh, R
Shanmugam, Mahesh
Konana, Vinaya Kumar
Mishra, Divyansh
Comparison of optical coherence tomography angiography and fundus fluorescein angiography features of retinal capillary hemangioblastoma
title Comparison of optical coherence tomography angiography and fundus fluorescein angiography features of retinal capillary hemangioblastoma
title_full Comparison of optical coherence tomography angiography and fundus fluorescein angiography features of retinal capillary hemangioblastoma
title_fullStr Comparison of optical coherence tomography angiography and fundus fluorescein angiography features of retinal capillary hemangioblastoma
title_full_unstemmed Comparison of optical coherence tomography angiography and fundus fluorescein angiography features of retinal capillary hemangioblastoma
title_short Comparison of optical coherence tomography angiography and fundus fluorescein angiography features of retinal capillary hemangioblastoma
title_sort comparison of optical coherence tomography angiography and fundus fluorescein angiography features of retinal capillary hemangioblastoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989523/
https://www.ncbi.nlm.nih.gov/pubmed/29786009
http://dx.doi.org/10.4103/ijo.IJO_1199_17
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