Cargando…

The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human

Missense mutations in the LRRK2 (Leucine-rich repeat protein kinase-2) and VPS35 genes result in autosomal dominant Parkinson's disease. The VPS35 gene encodes for the cargo-binding component of the retromer complex, while LRRK2 modulates vesicular trafficking by phosphorylating a subgroup of R...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mir, Rafeeq, Tonelli, Francesca, Lis, Pawel, Macartney, Thomas, Polinski, Nicole K., Martinez, Terina N., Chou, Meng-Yun, Howden, Andrew J.M., König, Theresa, Hotzy, Christoph, Milenkovic, Ivan, Brücke, Thomas, Zimprich, Alexander, Sammler, Esther, Alessi, Dario R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989534/ https://www.ncbi.nlm.nih.gov/pubmed/29743203 http://dx.doi.org/10.1042/BCJ20180248

Ejemplares similares

Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites
por: Nirujogi, Raja S., et al.
Publicado: (2021)

Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils
por: Fan, Ying, et al.
Publicado: (2018)

Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson’s disease
por: Gomes, Sara, et al.
Publicado: (2023)

Rab29 activation of the Parkinson's disease‐associated LRRK2 kinase
por: Purlyte, Elena, et al.
Publicado: (2017)

Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms
por: Malik, Asad U., et al.
Publicado: (2021)

Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase
por: Lis, Pawel, et al.
Publicado: (2018)

Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity
por: Kalogeropulou, Alexia F., et al.
Publicado: (2020)

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins
por: Berndsen, Kerryn, et al.
Publicado: (2019)

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis
por: Steger, Martin, et al.
Publicado: (2017)

Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibition
por: Kadgien, Chelsie A., et al.
Publicado: (2021)

Accurate MS-based Rab10 Phosphorylation Stoichiometry Determination as Readout for LRRK2 Activity in Parkinson's Disease
por: Karayel, Özge, et al.
Publicado: (2020)

Mitochondrial and Clearance Impairment in p.D620N VPS35 Patient‐Derived Neurons
por: Hanss, Zoé, et al.
Publicado: (2020)

VPS35 D620N knockin mice recapitulate cardinal features of Parkinson’s disease
por: Niu, Mengyue, et al.
Publicado: (2021)

Membrane association but not identity is required for LRRK2 activation and phosphorylation of Rab GTPases
por: Gomez, Rachel C., et al.
Publicado: (2019)

Altered dopamine release and monoamine transporters in Vps35 p.D620N knock-in mice
por: Cataldi, Stefano, et al.
Publicado: (2018)

Parkinson’s disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration
por: Chen, Xi, et al.
Publicado: (2019)

Altered striatal dopamine levels in Parkinson’s disease VPS35 D620N mutant transgenic aged mice
por: Vanan, Sarivin, et al.
Publicado: (2020)

Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation
por: McGough, Ian J., et al.
Publicado: (2014)

Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation
por: McGough, Ian J., et al.
Publicado: (2014)

Endosomal dysfunction in iPSC-derived neural cells from Parkinson’s disease patients with VPS35 D620N
por: Bono, Keiko, et al.
Publicado: (2020)

Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors
por: Ito, Genta, et al.
Publicado: (2016)

LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation
por: Bae, Eun-Jin, et al.
Publicado: (2018)

Endogenous Rab38 regulates LRRK2’s membrane recruitment and substrate Rab phosphorylation in melanocytes
por: Unapanta, Alexandra, et al.
Publicado: (2023)

Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding
por: Kalogeropulou, Alexia F., et al.
Publicado: (2022)

(D620N) VPS35 causes the impairment of Wnt/β-catenin signaling cascade and mitochondrial dysfunction in a PARK17 knockin mouse model
por: Chiu, Ching-Chi, et al.
Publicado: (2020)

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
por: Steger, Martin, et al.
Publicado: (2016)

Rare variants in LRRK1 and Parkinson's disease
por: Schulte, Eva C., et al.
Publicado: (2013)

Screening for VPS35 mutations in Parkinson's disease
por: Sheerin, Una-Marie, et al.
Publicado: (2012)

Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes
por: Tremel, Shirley, et al.
Publicado: (2021)

Rab GTPases as Physiological Substrates of LRRK2 Kinase
por: Seol, Wongi, et al.
Publicado: (2019)

Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2
por: Waschbüsch, Dieter, et al.
Publicado: (2020)

Vps34 and the Armus/TBC-2 Rab GAPs: Putting the brakes on the endosomal Rab5 and Rab7 GTPases
por: Law, Fiona, et al.
Publicado: (2017)

‘Up with the LRRK’: a phosphorylated Rab10 assay for evaluation of LRRK2 activity and inhibitor engagement
por: Eyers, Patrick A.
Publicado: (2016)

R1441G but not G2019S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophils
por: Fan, Ying, et al.
Publicado: (2021)

VPS35 leaves endosomes lost in transition
por: Leslie, Mitch
Publicado: (2011)

VPS35, the Retromer Complex and Parkinson’s Disease
por: Williams, Erin T., et al.
Publicado: (2017)

Vacuolar protein sorting 35 (Vps35) rescues locomotor deficits and shortened lifespan in Drosophila expressing a Parkinson’s disease mutant of Leucine-rich repeat kinase 2 (LRRK2)
por: Linhart, Radek, et al.
Publicado: (2014)

Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration
por: Jeong, Ga Ram, et al.
Publicado: (2018)

The Emerging Functions of LRRK2 and Rab GTPases in the Endolysosomal System
por: Kuwahara, Tomoki, et al.
Publicado: (2020)

Dual arginine recognition of LRRK2 phosphorylated Rab GTPases
por: Waschbüsch, Dieter, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_8m01r0036jbdi3hb4tav9esr70