Tissue Metabolic Changes Drive Cytokine Responses to Mycobacterium tuberculosis

Cellular metabolism can influence host immune responses to Mycobacterium tuberculosis. Using a systems biology approach, differential expression of 292 metabolic genes involved in glycolysis, glutathione, pyrimidine, and inositol phosphate pathways was evident at the site of a human tuberculin skin...

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Detalles Bibliográficos
Autores principales: Lachmandas, Ekta, Rios-Miguel, Ana B, Koeken, Valerie A C M, van der Pasch, Eva, Kumar, Vinod, Matzaraki, Vasiliki, Li, Yang, Oosting, Marije, Joosten, Leo A B, Notebaart, Richard A, Noursadeghi, Mahdad, Netea, Mihai G, van Crevel, Reinout, Pollara, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989606/
https://www.ncbi.nlm.nih.gov/pubmed/29618104
http://dx.doi.org/10.1093/infdis/jiy173
Descripción
Sumario:Cellular metabolism can influence host immune responses to Mycobacterium tuberculosis. Using a systems biology approach, differential expression of 292 metabolic genes involved in glycolysis, glutathione, pyrimidine, and inositol phosphate pathways was evident at the site of a human tuberculin skin test challenge in patients with active tuberculosis infection. For 28 metabolic genes, we identified single nucleotide polymorphisms that were trans-acting for in vitro cytokine responses to M. tuberculosis stimulation, including glutathione and pyrimidine metabolism genes that alter production of Th1 and Th17 cytokines. Our findings identify novel therapeutic targets in host metabolism that may shape protective immunity to tuberculosis.

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