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Development and validation of an oxygen dissociation assay, a screening platform for discovering, and characterizing hemoglobin–oxygen affinity modifiers

INTRODUCTION: Hemoglobin (Hb) is a critical molecule necessary for all vertebrates to maintain aerobic metabolism. Hb–oxygen (O(2)) affinity modifiers have been studied to address various diseases including sickle cell disease, hypoxemia, tumor hypoxia, and wound healing. However, drug development o...

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Detalles Bibliográficos
Autores principales:	Patel, Mira P, Siu, Vincent, Silva-Garcia, Abel, Xu, Qing, Li, Zhe, Oksenberg, Donna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989706/ https://www.ncbi.nlm.nih.gov/pubmed/29910606 http://dx.doi.org/10.2147/DDDT.S157570

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