Liquid biopsy: a new source of candidate biomarkers in amyotrophic lateral sclerosis

Noninvasive tests to diagnose and monitor the progression of neurodegenerative disorders have been a challenge for decades. The aim of this study was to explore the feasibility of applying liquid biopsy procedures to patients with a neurodegenerative disease such as amyotrophic lateral sclerosis (AL...

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Autores principales: Mendioroz, Maite, Martínez‐Merino, Leyre, Blanco‐Luquin, Idoia, Urdánoz, Amaya, Roldán, Miren, Jericó, Ivonne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989775/
https://www.ncbi.nlm.nih.gov/pubmed/29928659
http://dx.doi.org/10.1002/acn3.565
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author Mendioroz, Maite
Martínez‐Merino, Leyre
Blanco‐Luquin, Idoia
Urdánoz, Amaya
Roldán, Miren
Jericó, Ivonne
author_facet Mendioroz, Maite
Martínez‐Merino, Leyre
Blanco‐Luquin, Idoia
Urdánoz, Amaya
Roldán, Miren
Jericó, Ivonne
author_sort Mendioroz, Maite
collection PubMed
description Noninvasive tests to diagnose and monitor the progression of neurodegenerative disorders have been a challenge for decades. The aim of this study was to explore the feasibility of applying liquid biopsy procedures to patients with a neurodegenerative disease such as amyotrophic lateral sclerosis (ALS). We isolated plasma cell‐free DNA (cfDNA) in 20 ALS patients and 20 controls and used cfDNA to identify a novel differentially methylated mark in RHBDF2 gene in ALS patients compared to controls. Our findings support the notion that liquid biopsy may be applied to living patients as a source of potential epigenetic biomarkers for neurodegenerative disorders.
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spelling pubmed-59897752018-06-20 Liquid biopsy: a new source of candidate biomarkers in amyotrophic lateral sclerosis Mendioroz, Maite Martínez‐Merino, Leyre Blanco‐Luquin, Idoia Urdánoz, Amaya Roldán, Miren Jericó, Ivonne Ann Clin Transl Neurol Brief Communication Noninvasive tests to diagnose and monitor the progression of neurodegenerative disorders have been a challenge for decades. The aim of this study was to explore the feasibility of applying liquid biopsy procedures to patients with a neurodegenerative disease such as amyotrophic lateral sclerosis (ALS). We isolated plasma cell‐free DNA (cfDNA) in 20 ALS patients and 20 controls and used cfDNA to identify a novel differentially methylated mark in RHBDF2 gene in ALS patients compared to controls. Our findings support the notion that liquid biopsy may be applied to living patients as a source of potential epigenetic biomarkers for neurodegenerative disorders. John Wiley and Sons Inc. 2018-04-16 /pmc/articles/PMC5989775/ /pubmed/29928659 http://dx.doi.org/10.1002/acn3.565 Text en © 2018 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Brief Communication
Mendioroz, Maite
Martínez‐Merino, Leyre
Blanco‐Luquin, Idoia
Urdánoz, Amaya
Roldán, Miren
Jericó, Ivonne
Liquid biopsy: a new source of candidate biomarkers in amyotrophic lateral sclerosis
title Liquid biopsy: a new source of candidate biomarkers in amyotrophic lateral sclerosis
title_full Liquid biopsy: a new source of candidate biomarkers in amyotrophic lateral sclerosis
title_fullStr Liquid biopsy: a new source of candidate biomarkers in amyotrophic lateral sclerosis
title_full_unstemmed Liquid biopsy: a new source of candidate biomarkers in amyotrophic lateral sclerosis
title_short Liquid biopsy: a new source of candidate biomarkers in amyotrophic lateral sclerosis
title_sort liquid biopsy: a new source of candidate biomarkers in amyotrophic lateral sclerosis
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989775/
https://www.ncbi.nlm.nih.gov/pubmed/29928659
http://dx.doi.org/10.1002/acn3.565
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