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Collagen type I induces EGFR‐TKI resistance in EGFR‐mutated cancer cells by mTOR activation through Akt‐independent pathway

Primary resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) is a serious problem in lung adenocarcinoma patients harboring EGFR mutations. The aim of this study was to examine whether and how collagen type I (Col I), the most abundantly deposited matrix in tumor str...

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Detalles Bibliográficos
Autores principales:	Yamazaki, Shota, Higuchi, Youichi, Ishibashi, Masayuki, Hashimoto, Hiroko, Yasunaga, Masahiro, Matsumura, Yasuhiro, Tsuchihara, Katsuya, Tsuboi, Masahiro, Goto, Koichi, Ochiai, Atsushi, Ishii, Genichiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989854/ https://www.ncbi.nlm.nih.gov/pubmed/29701925 http://dx.doi.org/10.1111/cas.13624

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