Long non‐coding RNA‐CTD‐2108O9.1 represses breast cancer metastasis by influencing leukemia inhibitory factor receptor

Breast cancer (BC) is an aggressive malignant disease in women worldwide with a high tendency to metastasize. However, important biomarkers for BC metastasis remain largely undefined. In the present study, we identified that long non‐coding RNA‐CTD‐2108O9.1 is downregulated in BC tissues and cells a...

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Autores principales: Wang, Mozhi, Wang, Mengshen, Wang, Zhenning, Yu, Xueting, Song, Yongxi, Wang, Chong, Xu, Yujie, Wei, Fengheng, Zhao, Yi, Xu, Yingying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989867/
https://www.ncbi.nlm.nih.gov/pubmed/29603493
http://dx.doi.org/10.1111/cas.13592
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author Wang, Mozhi
Wang, Mengshen
Wang, Zhenning
Yu, Xueting
Song, Yongxi
Wang, Chong
Xu, Yujie
Wei, Fengheng
Zhao, Yi
Xu, Yingying
author_facet Wang, Mozhi
Wang, Mengshen
Wang, Zhenning
Yu, Xueting
Song, Yongxi
Wang, Chong
Xu, Yujie
Wei, Fengheng
Zhao, Yi
Xu, Yingying
author_sort Wang, Mozhi
collection PubMed
description Breast cancer (BC) is an aggressive malignant disease in women worldwide with a high tendency to metastasize. However, important biomarkers for BC metastasis remain largely undefined. In the present study, we identified that long non‐coding RNA‐CTD‐2108O9.1 is downregulated in BC tissues and cells and acts as a metastatic inhibitor of BC. Mechanistic investigation determined that lncRNA‐CTD‐2108O9.1 represses metastasis by targeting leukemia inhibitory factor receptor (LIFR), which is designated as a metastasis suppressor in BC. Our study characterizes a significant tumor suppressor active in BC metastasis repression through the known metastasis inhibitor LIFR.
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spelling pubmed-59898672018-06-20 Long non‐coding RNA‐CTD‐2108O9.1 represses breast cancer metastasis by influencing leukemia inhibitory factor receptor Wang, Mozhi Wang, Mengshen Wang, Zhenning Yu, Xueting Song, Yongxi Wang, Chong Xu, Yujie Wei, Fengheng Zhao, Yi Xu, Yingying Cancer Sci Original Articles Breast cancer (BC) is an aggressive malignant disease in women worldwide with a high tendency to metastasize. However, important biomarkers for BC metastasis remain largely undefined. In the present study, we identified that long non‐coding RNA‐CTD‐2108O9.1 is downregulated in BC tissues and cells and acts as a metastatic inhibitor of BC. Mechanistic investigation determined that lncRNA‐CTD‐2108O9.1 represses metastasis by targeting leukemia inhibitory factor receptor (LIFR), which is designated as a metastasis suppressor in BC. Our study characterizes a significant tumor suppressor active in BC metastasis repression through the known metastasis inhibitor LIFR. John Wiley and Sons Inc. 2018-04-28 2018-06 /pmc/articles/PMC5989867/ /pubmed/29603493 http://dx.doi.org/10.1111/cas.13592 Text en © 2018 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Wang, Mozhi
Wang, Mengshen
Wang, Zhenning
Yu, Xueting
Song, Yongxi
Wang, Chong
Xu, Yujie
Wei, Fengheng
Zhao, Yi
Xu, Yingying
Long non‐coding RNA‐CTD‐2108O9.1 represses breast cancer metastasis by influencing leukemia inhibitory factor receptor
title Long non‐coding RNA‐CTD‐2108O9.1 represses breast cancer metastasis by influencing leukemia inhibitory factor receptor
title_full Long non‐coding RNA‐CTD‐2108O9.1 represses breast cancer metastasis by influencing leukemia inhibitory factor receptor
title_fullStr Long non‐coding RNA‐CTD‐2108O9.1 represses breast cancer metastasis by influencing leukemia inhibitory factor receptor
title_full_unstemmed Long non‐coding RNA‐CTD‐2108O9.1 represses breast cancer metastasis by influencing leukemia inhibitory factor receptor
title_short Long non‐coding RNA‐CTD‐2108O9.1 represses breast cancer metastasis by influencing leukemia inhibitory factor receptor
title_sort long non‐coding rna‐ctd‐2108o9.1 represses breast cancer metastasis by influencing leukemia inhibitory factor receptor
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989867/
https://www.ncbi.nlm.nih.gov/pubmed/29603493
http://dx.doi.org/10.1111/cas.13592
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