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Cross-protection induced by VA-MENGOC-BC® vaccine

I would like to comment on the article “Commentary: Impact of meningococcal group B OMV vaccines, beyond their brief”, DOI: 10.1080/21645515.2017.1381810. The author states that meningococcal group B OMVs vaccines –such as VA-MENGOC-BC®– may induce moderate protection against Neisseria gonorrhoeae....

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Autor principal: Ochoa-Azze, Rolando Felipe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989903/
https://www.ncbi.nlm.nih.gov/pubmed/29420119
http://dx.doi.org/10.1080/21645515.2018.1438028
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author Ochoa-Azze, Rolando Felipe
author_facet Ochoa-Azze, Rolando Felipe
author_sort Ochoa-Azze, Rolando Felipe
collection PubMed
description I would like to comment on the article “Commentary: Impact of meningococcal group B OMV vaccines, beyond their brief”, DOI: 10.1080/21645515.2017.1381810. The author states that meningococcal group B OMVs vaccines –such as VA-MENGOC-BC®– may induce moderate protection against Neisseria gonorrhoeae. I agree. However, the author states that “there was no evidence of effectiveness in the younger children.” The effectiveness of VA-MENGOC-BC® in heterologous contexts has been higher than 80% in individuals older than 4 years old, but the effectiveness in younger children should not be undervalued; it has usually been higher than 60%, and results markedly higher when evaluated based on mortality rates. There is strong evidence that VA-MENGOC-BC® may induce cross-protection against heterologous N. meningitidis strains and N. gonorrhoeae.
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spelling pubmed-59899032018-06-07 Cross-protection induced by VA-MENGOC-BC® vaccine Ochoa-Azze, Rolando Felipe Hum Vaccin Immunother Commentary I would like to comment on the article “Commentary: Impact of meningococcal group B OMV vaccines, beyond their brief”, DOI: 10.1080/21645515.2017.1381810. The author states that meningococcal group B OMVs vaccines –such as VA-MENGOC-BC®– may induce moderate protection against Neisseria gonorrhoeae. I agree. However, the author states that “there was no evidence of effectiveness in the younger children.” The effectiveness of VA-MENGOC-BC® in heterologous contexts has been higher than 80% in individuals older than 4 years old, but the effectiveness in younger children should not be undervalued; it has usually been higher than 60%, and results markedly higher when evaluated based on mortality rates. There is strong evidence that VA-MENGOC-BC® may induce cross-protection against heterologous N. meningitidis strains and N. gonorrhoeae. Taylor & Francis 2018-02-26 /pmc/articles/PMC5989903/ /pubmed/29420119 http://dx.doi.org/10.1080/21645515.2018.1438028 Text en © 2018 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Commentary
Ochoa-Azze, Rolando Felipe
Cross-protection induced by VA-MENGOC-BC® vaccine
title Cross-protection induced by VA-MENGOC-BC® vaccine
title_full Cross-protection induced by VA-MENGOC-BC® vaccine
title_fullStr Cross-protection induced by VA-MENGOC-BC® vaccine
title_full_unstemmed Cross-protection induced by VA-MENGOC-BC® vaccine
title_short Cross-protection induced by VA-MENGOC-BC® vaccine
title_sort cross-protection induced by va-mengoc-bc® vaccine
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989903/
https://www.ncbi.nlm.nih.gov/pubmed/29420119
http://dx.doi.org/10.1080/21645515.2018.1438028
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