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Non-senescent Hydra tolerates severe disturbances in the nuclear lamina
The cnidarian Hydra is known for its unlimited lifespan and non-senescence, due to the indefinite self-renewal capacity of its stem cells. While proteins of the Lamin family are recognized as critical factors affecting senescence and longevity in human and mice, their putative role in the extreme lo...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990382/ https://www.ncbi.nlm.nih.gov/pubmed/29754147 http://dx.doi.org/10.18632/aging.101440 |
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author | Klimovich, Alexander Rehm, Arvid Wittlieb, Jörg Herbst, Eva-Maria Benavente, Ricardo Bosch, Thomas C.G. |
author_facet | Klimovich, Alexander Rehm, Arvid Wittlieb, Jörg Herbst, Eva-Maria Benavente, Ricardo Bosch, Thomas C.G. |
author_sort | Klimovich, Alexander |
collection | PubMed |
description | The cnidarian Hydra is known for its unlimited lifespan and non-senescence, due to the indefinite self-renewal capacity of its stem cells. While proteins of the Lamin family are recognized as critical factors affecting senescence and longevity in human and mice, their putative role in the extreme longevity and non-senescence in long-living animals remains unknown. Here we analyze the role of a single lamin protein in non-senescence of Hydra. We demonstrate that proliferation of stem cells in Hydra is robust against the disturbance of Lamin expression and localization. While Lamin is indispensable for Hydra, the stem cells tolerate overexpression, downregulation and mislocalization of Lamin, and disturbances in the nuclear envelope structure. This extraordinary robustness may underlie the indefinite self-renewal capacity of stem cells and the non-senescence of Hydra. A relatively low complexity of the nuclear envelope architecture in basal Metazoa might allow for their extreme lifespans, while an increasing complexity of the nuclear architecture in bilaterians resulted in restricted lifespans. |
format | Online Article Text |
id | pubmed-5990382 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-59903822018-06-07 Non-senescent Hydra tolerates severe disturbances in the nuclear lamina Klimovich, Alexander Rehm, Arvid Wittlieb, Jörg Herbst, Eva-Maria Benavente, Ricardo Bosch, Thomas C.G. Aging (Albany NY) Research Paper The cnidarian Hydra is known for its unlimited lifespan and non-senescence, due to the indefinite self-renewal capacity of its stem cells. While proteins of the Lamin family are recognized as critical factors affecting senescence and longevity in human and mice, their putative role in the extreme longevity and non-senescence in long-living animals remains unknown. Here we analyze the role of a single lamin protein in non-senescence of Hydra. We demonstrate that proliferation of stem cells in Hydra is robust against the disturbance of Lamin expression and localization. While Lamin is indispensable for Hydra, the stem cells tolerate overexpression, downregulation and mislocalization of Lamin, and disturbances in the nuclear envelope structure. This extraordinary robustness may underlie the indefinite self-renewal capacity of stem cells and the non-senescence of Hydra. A relatively low complexity of the nuclear envelope architecture in basal Metazoa might allow for their extreme lifespans, while an increasing complexity of the nuclear architecture in bilaterians resulted in restricted lifespans. Impact Journals 2018-05-10 /pmc/articles/PMC5990382/ /pubmed/29754147 http://dx.doi.org/10.18632/aging.101440 Text en Copyright © 2018 Klimovich et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Paper Klimovich, Alexander Rehm, Arvid Wittlieb, Jörg Herbst, Eva-Maria Benavente, Ricardo Bosch, Thomas C.G. Non-senescent Hydra tolerates severe disturbances in the nuclear lamina |
title | Non-senescent Hydra tolerates severe disturbances in the nuclear lamina |
title_full | Non-senescent Hydra tolerates severe disturbances in the nuclear lamina |
title_fullStr | Non-senescent Hydra tolerates severe disturbances in the nuclear lamina |
title_full_unstemmed | Non-senescent Hydra tolerates severe disturbances in the nuclear lamina |
title_short | Non-senescent Hydra tolerates severe disturbances in the nuclear lamina |
title_sort | non-senescent hydra tolerates severe disturbances in the nuclear lamina |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990382/ https://www.ncbi.nlm.nih.gov/pubmed/29754147 http://dx.doi.org/10.18632/aging.101440 |
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