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Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging

Non-enzymatic protein modifications occur inevitably in all living systems. Products of such modifications accumulate during aging of cells and organisms and may contribute to their age-related functional deterioration. This review presents the formation of irreversible protein modifications such as...

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Detalles Bibliográficos
Autores principales: Gonos, Efstathios S., Kapetanou, Marianna, Sereikaite, Jolanta, Bartosz, Grzegorz, Naparło, Katarzyna, Grzesik, Michalina, Sadowska-Bartosz, Izabela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990388/
https://www.ncbi.nlm.nih.gov/pubmed/29779015
http://dx.doi.org/10.18632/aging.101450
Descripción
Sumario:Non-enzymatic protein modifications occur inevitably in all living systems. Products of such modifications accumulate during aging of cells and organisms and may contribute to their age-related functional deterioration. This review presents the formation of irreversible protein modifications such as carbonylation, nitration and chlorination, modifications by 4-hydroxynonenal, removal of modified proteins and accumulation of these protein modifications during aging of humans and model organisms, and their enhanced accumulation in age-related brain diseases.