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Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging
Non-enzymatic protein modifications occur inevitably in all living systems. Products of such modifications accumulate during aging of cells and organisms and may contribute to their age-related functional deterioration. This review presents the formation of irreversible protein modifications such as...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990388/ https://www.ncbi.nlm.nih.gov/pubmed/29779015 http://dx.doi.org/10.18632/aging.101450 |
| _version_ | 1783329571820535808 |
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| author | Gonos, Efstathios S. Kapetanou, Marianna Sereikaite, Jolanta Bartosz, Grzegorz Naparło, Katarzyna Grzesik, Michalina Sadowska-Bartosz, Izabela |
| author_facet | Gonos, Efstathios S. Kapetanou, Marianna Sereikaite, Jolanta Bartosz, Grzegorz Naparło, Katarzyna Grzesik, Michalina Sadowska-Bartosz, Izabela |
| author_sort | Gonos, Efstathios S. |
| collection | PubMed |
| description | Non-enzymatic protein modifications occur inevitably in all living systems. Products of such modifications accumulate during aging of cells and organisms and may contribute to their age-related functional deterioration. This review presents the formation of irreversible protein modifications such as carbonylation, nitration and chlorination, modifications by 4-hydroxynonenal, removal of modified proteins and accumulation of these protein modifications during aging of humans and model organisms, and their enhanced accumulation in age-related brain diseases. |
| format | Online Article Text |
| id | pubmed-5990388 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Impact Journals |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-59903882018-06-07 Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging Gonos, Efstathios S. Kapetanou, Marianna Sereikaite, Jolanta Bartosz, Grzegorz Naparło, Katarzyna Grzesik, Michalina Sadowska-Bartosz, Izabela Aging (Albany NY) Review Non-enzymatic protein modifications occur inevitably in all living systems. Products of such modifications accumulate during aging of cells and organisms and may contribute to their age-related functional deterioration. This review presents the formation of irreversible protein modifications such as carbonylation, nitration and chlorination, modifications by 4-hydroxynonenal, removal of modified proteins and accumulation of these protein modifications during aging of humans and model organisms, and their enhanced accumulation in age-related brain diseases. Impact Journals 2018-05-17 /pmc/articles/PMC5990388/ /pubmed/29779015 http://dx.doi.org/10.18632/aging.101450 Text en Copyright © 2018 Gonos et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Review Gonos, Efstathios S. Kapetanou, Marianna Sereikaite, Jolanta Bartosz, Grzegorz Naparło, Katarzyna Grzesik, Michalina Sadowska-Bartosz, Izabela Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging |
| title | Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging |
| title_full | Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging |
| title_fullStr | Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging |
| title_full_unstemmed | Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging |
| title_short | Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging |
| title_sort | origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990388/ https://www.ncbi.nlm.nih.gov/pubmed/29779015 http://dx.doi.org/10.18632/aging.101450 |
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