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Modification of α-synuclein by lipid peroxidation products derived from polyunsaturated fatty acids promotes toxic oligomerization: its relevance to Parkinson disease

Recently, toxic α-synuclein oligomer, which can mediate cell-to-cell propagation is suggested to cause sporadic Parkinson disease. α-Synuclein interacts with membrane lipids especially polyunsaturated fatty acids to stabilize its three-dementional structure. Peroxidation of polyunsaturated fatty aci...

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Detalles Bibliográficos
Autores principales:	Shamoto-Nagai, Masayo, Hisaka, Shinsuke, Naoi, Makoto, Maruyama, Wakako
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	the Society for Free Radical Research Japan 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990400/ https://www.ncbi.nlm.nih.gov/pubmed/29892158 http://dx.doi.org/10.3164/jcbn.18-25

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