Cargando…

Modification of α-synuclein by lipid peroxidation products derived from polyunsaturated fatty acids promotes toxic oligomerization: its relevance to Parkinson disease

Recently, toxic α-synuclein oligomer, which can mediate cell-to-cell propagation is suggested to cause sporadic Parkinson disease. α-Synuclein interacts with membrane lipids especially polyunsaturated fatty acids to stabilize its three-dementional structure. Peroxidation of polyunsaturated fatty aci...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shamoto-Nagai, Masayo, Hisaka, Shinsuke, Naoi, Makoto, Maruyama, Wakako
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	the Society for Free Radical Research Japan 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990400/ https://www.ncbi.nlm.nih.gov/pubmed/29892158 http://dx.doi.org/10.3164/jcbn.18-25

Ejemplares similares

Neuroprotective Function of Rasagiline and Selegiline, Inhibitors of Type B Monoamine Oxidase, and Role of Monoamine Oxidases in Synucleinopathies
por: Naoi, Makoto, et al.
Publicado: (2022)

Mitochondria in Neuroprotection by Phytochemicals: Bioactive Polyphenols Modulate Mitochondrial Apoptosis System, Function and Structure
por: Naoi, Makoto, et al.
Publicado: (2019)

Seeking a Mechanism for the Toxicity of Oligomeric α-Synuclein
por: Roberts, Hazel L., et al.
Publicado: (2015)

Abnormal Salivary Total and Oligomeric Alpha-Synuclein in Parkinson’s Disease
por: Vivacqua, Giorgio, et al.
Publicado: (2016)

Formation of Toxic Oligomeric α-Synuclein Species in Living Cells
por: Outeiro, Tiago Fleming, et al.
Publicado: (2008)

Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies
por: Cascella, Roberta, et al.
Publicado: (2019)

Salivary total α-synuclein, oligomeric α-synuclein and SNCA variants in Parkinson’s disease patients
por: Kang, Wenyan, et al.
Publicado: (2016)

Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease
por: Majbour, Nour K., et al.
Publicado: (2016)

Correction: Formation of Toxic Oligomeric α-Synuclein Species in Living Cells
por: Outeiro, Tiago Fleming, et al.
Publicado: (2008)

Toxic Oligomeric Alpha-Synuclein Variants Present in Human Parkinson’s Disease Brains Are Differentially Generated in Mammalian Cell Models
por: Xin, Wei, et al.
Publicado: (2015)

Dopamine-Mediated Oxidation of Methionine 127 in α-Synuclein Causes Cytotoxicity and Oligomerization of α-Synuclein
por: Nakaso, Kazuhiro, et al.
Publicado: (2013)

The Role of Alpha-Synuclein Oligomerization and Aggregation in Cellular and Animal Models of Parkinson’s Disease
por: Wan, Oi Wan, et al.
Publicado: (2012)

Dataset of total, oligomeric alpha-synuclein and hemoglobin levels in plasma in Parkinson׳s disease
por: Emelyanov, A., et al.
Publicado: (2016)

Inhibiting α-Synuclein Oligomerization by Stable Cell-Penetrating β-Synuclein Fragments Recovers Phenotype of Parkinson's Disease Model Flies
por: Shaltiel-Karyo, Ronit, et al.
Publicado: (2010)

α-Synuclein and DJ-1 as Potential Biological Fluid Biomarkers for Parkinson’s Disease
por: Waragai, Masaaki, et al.
Publicado: (2010)

Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson’s disease genetically related mutants
por: Tosatto, Laura, et al.
Publicado: (2015)

O-GlcNAc modification blocks the aggregation and toxicity of the Parkinson’s disease associated protein α-synuclein
por: Marotta, Nicholas P., et al.
Publicado: (2015)

Drug Targeting of α-Synuclein Oligomerization in Synucleinopathies
por: Outeiro, Tiago Fleming, et al.
Publicado: (2008)

Microtubule Depolymerization Potentiates Alpha-Synuclein Oligomerization
por: Esteves, A. Raquel, et al.
Publicado: (2010)

LPS-induced mitochondrial dysfunction regulates innate immunity activation and α-synuclein oligomerization in Parkinson's disease
por: Esteves, A. Raquel, et al.
Publicado: (2023)

Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species
por: Iljina, Marija, et al.
Publicado: (2017)

DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of α-synuclein toxicity and oligomerization
por: Popova, Blagovesta, et al.
Publicado: (2021)

Acetylated α-Tubulin and α-Synuclein: Physiological Interplay and Contribution to α-Synuclein Oligomerization
por: Calogero, Alessandra Maria, et al.
Publicado: (2023)

Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD
por: Esteves, A. R., et al.
Publicado: (2011)

Membrane Permeabilization by Oligomeric α-Synuclein: In Search of the Mechanism
por: van Rooijen, Bart D., et al.
Publicado: (2010)

Preanalytical Stability of CSF Total and Oligomeric Alpha-Synuclein
por: Abdi, Ilham Y., et al.
Publicado: (2021)

Oligomerization by co-assembly of β-amyloid and α-synuclein
por: Kim, Jin Ryoun
Publicado: (2023)

Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis
por: Hughes, Craig D., et al.
Publicado: (2018)

Isotope-reinforced polyunsaturated fatty acids improve Parkinson’s disease-like phenotype in rats overexpressing α-synuclein
por: Beal, M. Flint, et al.
Publicado: (2020)

The Roles of Post-translational Modifications on α-Synuclein in the Pathogenesis of Parkinson’s Diseases
por: Zhang, Jiaming, et al.
Publicado: (2019)

Antibodies against Alpha-Synuclein Reduce Oligomerization in Living Cells
por: Näsström, Thomas, et al.
Publicado: (2011)

α-synuclein interacts with SOD1 and promotes its oligomerization
por: Helferich, Anika M., et al.
Publicado: (2015)

Identification of Synaptosomal Proteins Binding to Monomeric and Oligomeric α-Synuclein
por: Betzer, Cristine, et al.
Publicado: (2015)

Loss of Functional Alpha-Synuclein: A Toxic Event in Parkinson’s Disease?
por: Kanaan, Nicholas M., et al.
Publicado: (2012)

Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease
por: Emin, Derya, et al.
Publicado: (2022)

Galectin-3 shapes toxic alpha-synuclein strains in Parkinson’s disease
por: García-Revilla, Juan, et al.
Publicado: (2023)

Polyunsaturated Fatty Acids Drive Lipid Peroxidation during Ferroptosis
por: Mortensen, Michael S., et al.
Publicado: (2023)

Motor and Nonmotor Symptoms of Parkinson's Disease: Antagonistic Pleiotropy Phenomena Derived from α-Synuclein Evolvability?
por: Takamatsu, Yoshiki, et al.
Publicado: (2018)

Possible Alterations in β-Synuclein, the Non-Amyloidogenic Homologue of α-Synuclein, during Progression of Sporadic α-Synucleinopathies
por: Fujita, Masayo, et al.
Publicado: (2012)

Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson’s disease
por: Vicente Miranda, Hugo, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_g0t27j8us6a3qc479f3v3t7ui5