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Atomic Structures of Segments from TDP-43 LCD and insight into Reversible and Pathogenic Aggregation
The normally soluble TAR DNA Binding Protein 43 (TDP-43) is found aggregated both in reversible stress granules and irreversible pathogenic amyloid. In TDP-43, the low complexity domain (LCD) is believed to be involved in both types of aggregation. To discover the structural origins of these two mod...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990464/ https://www.ncbi.nlm.nih.gov/pubmed/29786080 http://dx.doi.org/10.1038/s41594-018-0064-2 |