Cargando…
Human Pluripotent Stem-Cell-Derived Cortical Neurons Integrate Functionally into the Lesioned Adult Murine Visual Cortex in an Area-Specific Way
The transplantation of pluripotent stem-cell-derived neurons constitutes a promising avenue for the treatment of several brain diseases. However, their potential for the repair of the cerebral cortex remains unclear, given its complexity and neuronal diversity. Here, we show that human visual cortic...
Autores principales: | Espuny-Camacho, Ira, Michelsen, Kimmo A., Linaro, Daniele, Bilheu, Angéline, Acosta-Verdugo, Sandra, Herpoel, Adèle, Giugliano, Michele, Gaillard, Afsaneh, Vanderhaeghen, Pierre |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990494/ https://www.ncbi.nlm.nih.gov/pubmed/29847802 http://dx.doi.org/10.1016/j.celrep.2018.04.094 |
Ejemplares similares
-
Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation
por: Suzuki, Ikuo K., et al.
Publicado: (2018) -
Cortical Neurogenesis Requires Bcl6-Mediated Transcriptional Repression of Multiple Self-Renewal-Promoting Extrinsic Pathways
por: Bonnefont, Jerome, et al.
Publicado: (2019) -
CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors
por: Van Heurck, Roxane, et al.
Publicado: (2023) -
Xenotransplanted Human Cortical Neurons Reveal Species-Specific Development and Functional Integration into Mouse Visual Circuits
por: Linaro, Daniele, et al.
Publicado: (2019) -
Restoration of Progranulin Expression Rescues Cortical Neuron Generation in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia
por: Raitano, Susanna, et al.
Publicado: (2014)