Treatment with Botulinum Toxin for Refractory Fever Caused by Severe Spasticity: A Case Series

INTRODUCTION: Brain and spinal cord injuries may cause very severe spasticity that occasionally may be associated with persistent fever. CASE SERIES: We present 14 patients with spasticity and persistent fever, treated with botulinum toxin type A. Their spasticity improved and the fever resolved wit...

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Detalles Bibliográficos
Autores principales: Lester, Jacobo, Alvarez-Resendiz, Gerardo Esteban, Klériga, Enrique, Videgaray, Fernando, Zambito, Gerardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2018
Materias:
Case Series
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990504/
https://www.ncbi.nlm.nih.gov/pubmed/29383493
http://dx.doi.org/10.1007/s40120-018-0092-1
Descripción
Sumario:INTRODUCTION: Brain and spinal cord injuries may cause very severe spasticity that occasionally may be associated with persistent fever. CASE SERIES: We present 14 patients with spasticity and persistent fever, treated with botulinum toxin type A. Their spasticity improved and the fever resolved within a period no greater than 48 h. In all cases, infectious and other non-infectious causes were ruled out. CONCLUSIONS: When sustained tonic muscular activity is associated with a significant increase in body temperature and is refractory to the usual drugs used for hyperpyrexia, type A botulinum toxin may be an effective treatment option to control both spasticity and fever.

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