Treatment with Botulinum Toxin for Refractory Fever Caused by Severe Spasticity: A Case Series

INTRODUCTION: Brain and spinal cord injuries may cause very severe spasticity that occasionally may be associated with persistent fever. CASE SERIES: We present 14 patients with spasticity and persistent fever, treated with botulinum toxin type A. Their spasticity improved and the fever resolved wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Lester, Jacobo, Alvarez-Resendiz, Gerardo Esteban, Klériga, Enrique, Videgaray, Fernando, Zambito, Gerardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2018
Materias:
Case Series
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990504/
https://www.ncbi.nlm.nih.gov/pubmed/29383493
http://dx.doi.org/10.1007/s40120-018-0092-1
_version_ 1783329587029082112
author Lester, Jacobo
Alvarez-Resendiz, Gerardo Esteban
Klériga, Enrique
Videgaray, Fernando
Zambito, Gerardo
author_facet Lester, Jacobo
Alvarez-Resendiz, Gerardo Esteban
Klériga, Enrique
Videgaray, Fernando
Zambito, Gerardo
author_sort Lester, Jacobo
collection PubMed
description INTRODUCTION: Brain and spinal cord injuries may cause very severe spasticity that occasionally may be associated with persistent fever. CASE SERIES: We present 14 patients with spasticity and persistent fever, treated with botulinum toxin type A. Their spasticity improved and the fever resolved within a period no greater than 48 h. In all cases, infectious and other non-infectious causes were ruled out. CONCLUSIONS: When sustained tonic muscular activity is associated with a significant increase in body temperature and is refractory to the usual drugs used for hyperpyrexia, type A botulinum toxin may be an effective treatment option to control both spasticity and fever.
format Online
Article
Text
id pubmed-5990504
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Springer Healthcare
record_format MEDLINE/PubMed
spelling pubmed-59905042018-06-18 Treatment with Botulinum Toxin for Refractory Fever Caused by Severe Spasticity: A Case Series Lester, Jacobo Alvarez-Resendiz, Gerardo Esteban Klériga, Enrique Videgaray, Fernando Zambito, Gerardo Neurol Ther Case Series INTRODUCTION: Brain and spinal cord injuries may cause very severe spasticity that occasionally may be associated with persistent fever. CASE SERIES: We present 14 patients with spasticity and persistent fever, treated with botulinum toxin type A. Their spasticity improved and the fever resolved within a period no greater than 48 h. In all cases, infectious and other non-infectious causes were ruled out. CONCLUSIONS: When sustained tonic muscular activity is associated with a significant increase in body temperature and is refractory to the usual drugs used for hyperpyrexia, type A botulinum toxin may be an effective treatment option to control both spasticity and fever. Springer Healthcare 2018-01-30 /pmc/articles/PMC5990504/ /pubmed/29383493 http://dx.doi.org/10.1007/s40120-018-0092-1 Text en © The Author(s) 2018 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Case Series
Lester, Jacobo
Alvarez-Resendiz, Gerardo Esteban
Klériga, Enrique
Videgaray, Fernando
Zambito, Gerardo
Treatment with Botulinum Toxin for Refractory Fever Caused by Severe Spasticity: A Case Series
title Treatment with Botulinum Toxin for Refractory Fever Caused by Severe Spasticity: A Case Series
title_full Treatment with Botulinum Toxin for Refractory Fever Caused by Severe Spasticity: A Case Series
title_fullStr Treatment with Botulinum Toxin for Refractory Fever Caused by Severe Spasticity: A Case Series
title_full_unstemmed Treatment with Botulinum Toxin for Refractory Fever Caused by Severe Spasticity: A Case Series
title_short Treatment with Botulinum Toxin for Refractory Fever Caused by Severe Spasticity: A Case Series
title_sort treatment with botulinum toxin for refractory fever caused by severe spasticity: a case series
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990504/
https://www.ncbi.nlm.nih.gov/pubmed/29383493
http://dx.doi.org/10.1007/s40120-018-0092-1
work_keys_str_mv AT lesterjacobo treatmentwithbotulinumtoxinforrefractoryfevercausedbyseverespasticityacaseseries
AT alvarezresendizgerardoesteban treatmentwithbotulinumtoxinforrefractoryfevercausedbyseverespasticityacaseseries
AT klerigaenrique treatmentwithbotulinumtoxinforrefractoryfevercausedbyseverespasticityacaseseries
AT videgarayfernando treatmentwithbotulinumtoxinforrefractoryfevercausedbyseverespasticityacaseseries
AT zambitogerardo treatmentwithbotulinumtoxinforrefractoryfevercausedbyseverespasticityacaseseries

Ejemplares similares