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Physiology of Hyperuricemia and Urate-Lowering Treatments
Gout is the most common form of inflammatory arthritis and is a multifactorial disease typically characterized by hyperuricemia and monosodium urate crystal deposition predominantly in, but not limited to, the joints and the urinary tract. The prevalence of gout and hyperuricemia has increased in de...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990632/ https://www.ncbi.nlm.nih.gov/pubmed/29904633 http://dx.doi.org/10.3389/fmed.2018.00160 |
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author | Benn, Caroline L. Dua, Pinky Gurrell, Rachel Loudon, Peter Pike, Andrew Storer, R. Ian Vangjeli, Ciara |
author_facet | Benn, Caroline L. Dua, Pinky Gurrell, Rachel Loudon, Peter Pike, Andrew Storer, R. Ian Vangjeli, Ciara |
author_sort | Benn, Caroline L. |
collection | PubMed |
description | Gout is the most common form of inflammatory arthritis and is a multifactorial disease typically characterized by hyperuricemia and monosodium urate crystal deposition predominantly in, but not limited to, the joints and the urinary tract. The prevalence of gout and hyperuricemia has increased in developed countries over the past two decades and research into the area has become progressively more active. We review the current field of knowledge with emphasis on active areas of hyperuricemia research including the underlying physiology, genetics and epidemiology, with a focus on studies which suggest association of hyperuricemia with common comorbidities including cardiovascular disease, renal insufficiency, metabolic syndrome and diabetes. Finally, we discuss current therapies and emerging drug discovery efforts aimed at delivering an optimized clinical treatment strategy. |
format | Online Article Text |
id | pubmed-5990632 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-59906322018-06-14 Physiology of Hyperuricemia and Urate-Lowering Treatments Benn, Caroline L. Dua, Pinky Gurrell, Rachel Loudon, Peter Pike, Andrew Storer, R. Ian Vangjeli, Ciara Front Med (Lausanne) Medicine Gout is the most common form of inflammatory arthritis and is a multifactorial disease typically characterized by hyperuricemia and monosodium urate crystal deposition predominantly in, but not limited to, the joints and the urinary tract. The prevalence of gout and hyperuricemia has increased in developed countries over the past two decades and research into the area has become progressively more active. We review the current field of knowledge with emphasis on active areas of hyperuricemia research including the underlying physiology, genetics and epidemiology, with a focus on studies which suggest association of hyperuricemia with common comorbidities including cardiovascular disease, renal insufficiency, metabolic syndrome and diabetes. Finally, we discuss current therapies and emerging drug discovery efforts aimed at delivering an optimized clinical treatment strategy. Frontiers Media S.A. 2018-05-31 /pmc/articles/PMC5990632/ /pubmed/29904633 http://dx.doi.org/10.3389/fmed.2018.00160 Text en Copyright © 2018 Benn, Dua, Gurrell, Loudon, Pike, Storer and Vangjeli. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Benn, Caroline L. Dua, Pinky Gurrell, Rachel Loudon, Peter Pike, Andrew Storer, R. Ian Vangjeli, Ciara Physiology of Hyperuricemia and Urate-Lowering Treatments |
title | Physiology of Hyperuricemia and Urate-Lowering Treatments |
title_full | Physiology of Hyperuricemia and Urate-Lowering Treatments |
title_fullStr | Physiology of Hyperuricemia and Urate-Lowering Treatments |
title_full_unstemmed | Physiology of Hyperuricemia and Urate-Lowering Treatments |
title_short | Physiology of Hyperuricemia and Urate-Lowering Treatments |
title_sort | physiology of hyperuricemia and urate-lowering treatments |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990632/ https://www.ncbi.nlm.nih.gov/pubmed/29904633 http://dx.doi.org/10.3389/fmed.2018.00160 |
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