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Transcriptional analyses provide new insight into the late-stage immune response of a diseased Caribbean coral
Increasing global temperatures due to climate change have resulted in respective increases in the severity and frequency of epizootics around the globe. Corals in particular have faced rapid declines due to disease outbreaks. Understanding immune responses and associated potential life-history trade...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society Publishing
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990752/ https://www.ncbi.nlm.nih.gov/pubmed/29892394 http://dx.doi.org/10.1098/rsos.172062 |
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author | Fuess, Lauren E. Mann, Whitney T. Jinks, Lea R. Brinkhuis, Vanessa Mydlarz, Laura D. |
author_facet | Fuess, Lauren E. Mann, Whitney T. Jinks, Lea R. Brinkhuis, Vanessa Mydlarz, Laura D. |
author_sort | Fuess, Lauren E. |
collection | PubMed |
description | Increasing global temperatures due to climate change have resulted in respective increases in the severity and frequency of epizootics around the globe. Corals in particular have faced rapid declines due to disease outbreaks. Understanding immune responses and associated potential life-history trade-offs is therefore a priority. In the autumn of 2011, a novel disease of octocorals of the genus Eunicea was first documented in the Florida Keys. Termed Eunicea Black Disease (EBD), the disease is easily identified by the dark appearance of affected tissue, caused by a strong melanization response on the part of the host. In order to better understand the response of corals to EBD, we conducted full transcriptome analysis of 3 healthy and 3 diseased specimens of Eunicea calyculata collected from offshore southeast Florida. Differential expression and protein analyses revealed a strong, diverse immune response to EBD characterized by phagocytosis, adhesion and melanization on the part of the host. Furthermore, coexpression network analyses suggested this might come at the cost of reduced cell cycle progression and growth. This is in accordance with past histological studies of naturally infected hard corals, suggesting that potential trade-offs during infection may affect post-outbreak recovery of reef ecosystems by reducing both organismal growth and fecundity. Our findings highlight the importance of considering factors beyond mortality when estimating effects of disease outbreaks on ecosystems. |
format | Online Article Text |
id | pubmed-5990752 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Royal Society Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-59907522018-06-11 Transcriptional analyses provide new insight into the late-stage immune response of a diseased Caribbean coral Fuess, Lauren E. Mann, Whitney T. Jinks, Lea R. Brinkhuis, Vanessa Mydlarz, Laura D. R Soc Open Sci Biology (Whole Organism) Increasing global temperatures due to climate change have resulted in respective increases in the severity and frequency of epizootics around the globe. Corals in particular have faced rapid declines due to disease outbreaks. Understanding immune responses and associated potential life-history trade-offs is therefore a priority. In the autumn of 2011, a novel disease of octocorals of the genus Eunicea was first documented in the Florida Keys. Termed Eunicea Black Disease (EBD), the disease is easily identified by the dark appearance of affected tissue, caused by a strong melanization response on the part of the host. In order to better understand the response of corals to EBD, we conducted full transcriptome analysis of 3 healthy and 3 diseased specimens of Eunicea calyculata collected from offshore southeast Florida. Differential expression and protein analyses revealed a strong, diverse immune response to EBD characterized by phagocytosis, adhesion and melanization on the part of the host. Furthermore, coexpression network analyses suggested this might come at the cost of reduced cell cycle progression and growth. This is in accordance with past histological studies of naturally infected hard corals, suggesting that potential trade-offs during infection may affect post-outbreak recovery of reef ecosystems by reducing both organismal growth and fecundity. Our findings highlight the importance of considering factors beyond mortality when estimating effects of disease outbreaks on ecosystems. The Royal Society Publishing 2018-05-16 /pmc/articles/PMC5990752/ /pubmed/29892394 http://dx.doi.org/10.1098/rsos.172062 Text en © 2018 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Biology (Whole Organism) Fuess, Lauren E. Mann, Whitney T. Jinks, Lea R. Brinkhuis, Vanessa Mydlarz, Laura D. Transcriptional analyses provide new insight into the late-stage immune response of a diseased Caribbean coral |
title | Transcriptional analyses provide new insight into the late-stage immune response of a diseased Caribbean coral |
title_full | Transcriptional analyses provide new insight into the late-stage immune response of a diseased Caribbean coral |
title_fullStr | Transcriptional analyses provide new insight into the late-stage immune response of a diseased Caribbean coral |
title_full_unstemmed | Transcriptional analyses provide new insight into the late-stage immune response of a diseased Caribbean coral |
title_short | Transcriptional analyses provide new insight into the late-stage immune response of a diseased Caribbean coral |
title_sort | transcriptional analyses provide new insight into the late-stage immune response of a diseased caribbean coral |
topic | Biology (Whole Organism) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990752/ https://www.ncbi.nlm.nih.gov/pubmed/29892394 http://dx.doi.org/10.1098/rsos.172062 |
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