A convenient and eco-friendly cerium(III) chloride-catalysed synthesis of methoxime derivatives of aromatic aldehydes and ketones

The use of CeCl(3)·7H(2)O as an efficient and eco-friendly promoter for the convenient synthesis of methoximes derived from aromatic aldehydes and ketones, is reported. The transformations entail the use of equimolar amounts of MeONH(2)·HCl and NaOAc in EtOH at 50°C, and no special precautions are n...

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Detalles Bibliográficos
Autores principales: Cortés, Iván, Kaufman, Teodoro S., Bracca, Andrea B. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society Publishing 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990813/
https://www.ncbi.nlm.nih.gov/pubmed/29892459
http://dx.doi.org/10.1098/rsos.180279
Descripción
Sumario:The use of CeCl(3)·7H(2)O as an efficient and eco-friendly promoter for the convenient synthesis of methoximes derived from aromatic aldehydes and ketones, is reported. The transformations entail the use of equimolar amounts of MeONH(2)·HCl and NaOAc in EtOH at 50°C, and no special precautions are needed with regard to the presence of oxygen. The scope and limitations of the transformation were studied and a reaction mechanism was proposed.

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