Copper-catalysed regioselective sulfenylation of indoles with sodium sulfinates

A copper-catalysed sulfenylation of indoles with sodium sulfinates that affords 3-sulfenylindoles in good-to-excellent yields in N,N-dimethyl formamide (DMF) is described. In the process, DMF serves not only as a solvent but also as a reductant. This transformation is easy to carry out and has mild...

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Detalles Bibliográficos
Autores principales: Luo, Xiaojun, Liu, Qiang, Zhu, Hongxia, Chen, Huoji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society Publishing 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990840/
https://www.ncbi.nlm.nih.gov/pubmed/29892452
http://dx.doi.org/10.1098/rsos.180170
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author Luo, Xiaojun
Liu, Qiang
Zhu, Hongxia
Chen, Huoji
author_facet Luo, Xiaojun
Liu, Qiang
Zhu, Hongxia
Chen, Huoji
author_sort Luo, Xiaojun
collection PubMed
description A copper-catalysed sulfenylation of indoles with sodium sulfinates that affords 3-sulfenylindoles in good-to-excellent yields in N,N-dimethyl formamide (DMF) is described. In the process, DMF serves not only as a solvent but also as a reductant. This transformation is easy to carry out and has mild reaction conditions and good functional group tolerance.
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spelling pubmed-59908402018-06-11 Copper-catalysed regioselective sulfenylation of indoles with sodium sulfinates Luo, Xiaojun Liu, Qiang Zhu, Hongxia Chen, Huoji R Soc Open Sci Chemistry A copper-catalysed sulfenylation of indoles with sodium sulfinates that affords 3-sulfenylindoles in good-to-excellent yields in N,N-dimethyl formamide (DMF) is described. In the process, DMF serves not only as a solvent but also as a reductant. This transformation is easy to carry out and has mild reaction conditions and good functional group tolerance. The Royal Society Publishing 2018-05-30 /pmc/articles/PMC5990840/ /pubmed/29892452 http://dx.doi.org/10.1098/rsos.180170 Text en © 2018 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Chemistry
Luo, Xiaojun
Liu, Qiang
Zhu, Hongxia
Chen, Huoji
Copper-catalysed regioselective sulfenylation of indoles with sodium sulfinates
title Copper-catalysed regioselective sulfenylation of indoles with sodium sulfinates
title_full Copper-catalysed regioselective sulfenylation of indoles with sodium sulfinates
title_fullStr Copper-catalysed regioselective sulfenylation of indoles with sodium sulfinates
title_full_unstemmed Copper-catalysed regioselective sulfenylation of indoles with sodium sulfinates
title_short Copper-catalysed regioselective sulfenylation of indoles with sodium sulfinates
title_sort copper-catalysed regioselective sulfenylation of indoles with sodium sulfinates
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990840/
https://www.ncbi.nlm.nih.gov/pubmed/29892452
http://dx.doi.org/10.1098/rsos.180170
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AT liuqiang coppercatalysedregioselectivesulfenylationofindoleswithsodiumsulfinates
AT zhuhongxia coppercatalysedregioselectivesulfenylationofindoleswithsodiumsulfinates
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