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Obesity is not associated with an increased risk of portal vein thrombosis in cirrhotic patients
AIM: To determine the impact of obesity on development of portal vein thrombosis in cirrhotic patients. BACKGROUND: Cirrhosis is a known risk factor for portal vein thrombosis (PVT). Evidence also points to obesity as being a risk factor for venous thromboembolism. Limited information is available o...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shaheed Beheshti University of Medical Sciences
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990917/ https://www.ncbi.nlm.nih.gov/pubmed/29910857 |
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author | Zakko, Alan T Kroner, Paul Nankani, Rooma Karagozian, Raffi |
author_facet | Zakko, Alan T Kroner, Paul Nankani, Rooma Karagozian, Raffi |
author_sort | Zakko, Alan |
collection | PubMed |
description | AIM: To determine the impact of obesity on development of portal vein thrombosis in cirrhotic patients. BACKGROUND: Cirrhosis is a known risk factor for portal vein thrombosis (PVT). Evidence also points to obesity as being a risk factor for venous thromboembolism. Limited information is available on how obesity impacts the development of PVT in cirrhotic patients. METHODS: This was a retrospective cohort study using the 2013 National Inpatient Sample. Patients older than 18 years with an ICD-9 CM code for any diagnosis of liver cirrhosis were included. There was no exclusion criteria. The primary outcome was the impact of obesity on development of PVT. Obesity was also sub-classified according to body-mass index (BMI). Secondary outcomes were in-hospital mortality, ICU admission, shock, TPN use, and resource utilization. Odds ratios (OR) and means were adjusted for age, gender, and ethnicity. RESULTS: We included 69,934 obese cirrhotics of which, 1,125 developed PVT (mean age 59 years, 35% female). Overall in-hospital mortality rates were 9% (11% with PVT vs 5% without PVT). On multivariate analysis, obesity was not associated with a significantly different adjusted OR for development of PVT compared to non-obese. When stratifying by obesity subtype, class 1 obesity was associated with increased odds of PVT (OR: 1.45, 95%CI: 1.06-1.96, p=0.02), while class 3 obesity was associated with a decreased odds of PVT (OR: 0.72, 95%CI: 0.58-0.88, p<0.01) compared to non-obese. CONCLUSION: Obesity is not associated with increased odds of PVT. |
format | Online Article Text |
id | pubmed-5990917 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Shaheed Beheshti University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-59909172018-06-15 Obesity is not associated with an increased risk of portal vein thrombosis in cirrhotic patients Zakko, Alan T Kroner, Paul Nankani, Rooma Karagozian, Raffi Gastroenterol Hepatol Bed Bench Original Article AIM: To determine the impact of obesity on development of portal vein thrombosis in cirrhotic patients. BACKGROUND: Cirrhosis is a known risk factor for portal vein thrombosis (PVT). Evidence also points to obesity as being a risk factor for venous thromboembolism. Limited information is available on how obesity impacts the development of PVT in cirrhotic patients. METHODS: This was a retrospective cohort study using the 2013 National Inpatient Sample. Patients older than 18 years with an ICD-9 CM code for any diagnosis of liver cirrhosis were included. There was no exclusion criteria. The primary outcome was the impact of obesity on development of PVT. Obesity was also sub-classified according to body-mass index (BMI). Secondary outcomes were in-hospital mortality, ICU admission, shock, TPN use, and resource utilization. Odds ratios (OR) and means were adjusted for age, gender, and ethnicity. RESULTS: We included 69,934 obese cirrhotics of which, 1,125 developed PVT (mean age 59 years, 35% female). Overall in-hospital mortality rates were 9% (11% with PVT vs 5% without PVT). On multivariate analysis, obesity was not associated with a significantly different adjusted OR for development of PVT compared to non-obese. When stratifying by obesity subtype, class 1 obesity was associated with increased odds of PVT (OR: 1.45, 95%CI: 1.06-1.96, p=0.02), while class 3 obesity was associated with a decreased odds of PVT (OR: 0.72, 95%CI: 0.58-0.88, p<0.01) compared to non-obese. CONCLUSION: Obesity is not associated with increased odds of PVT. Shaheed Beheshti University of Medical Sciences 2018 /pmc/articles/PMC5990917/ /pubmed/29910857 Text en ©2018 RIGLD, Research Institute for Gastroenterology and Liver Diseases This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Zakko, Alan T Kroner, Paul Nankani, Rooma Karagozian, Raffi Obesity is not associated with an increased risk of portal vein thrombosis in cirrhotic patients |
title | Obesity is not associated with an increased risk of portal vein thrombosis in cirrhotic patients |
title_full | Obesity is not associated with an increased risk of portal vein thrombosis in cirrhotic patients |
title_fullStr | Obesity is not associated with an increased risk of portal vein thrombosis in cirrhotic patients |
title_full_unstemmed | Obesity is not associated with an increased risk of portal vein thrombosis in cirrhotic patients |
title_short | Obesity is not associated with an increased risk of portal vein thrombosis in cirrhotic patients |
title_sort | obesity is not associated with an increased risk of portal vein thrombosis in cirrhotic patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990917/ https://www.ncbi.nlm.nih.gov/pubmed/29910857 |
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