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Optimal platelet function test for in-stent tissue protrusion following carotid artery stenting
PURPOSE: To determine the best platelet function test for in-stent tissue protrusion following carotid artery stenting (CAS). METHODS: Patients who underwent CAS were recruited prospectively in this observational study. Combination of aspirin 100 mg/day and clopidogrel 75 mg/day was administered for...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991223/ https://www.ncbi.nlm.nih.gov/pubmed/29552932 http://dx.doi.org/10.1177/0300060518762949 |
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author | Tsujimoto, Masanori Enomoto, Yukiko Miyai, Masafumi Egashira, Yusuke Iwama, Toru |
author_facet | Tsujimoto, Masanori Enomoto, Yukiko Miyai, Masafumi Egashira, Yusuke Iwama, Toru |
author_sort | Tsujimoto, Masanori |
collection | PubMed |
description | PURPOSE: To determine the best platelet function test for in-stent tissue protrusion following carotid artery stenting (CAS). METHODS: Patients who underwent CAS were recruited prospectively in this observational study. Combination of aspirin 100 mg/day and clopidogrel 75 mg/day was administered for a minimum of 7 days prior to procedure. Platelet aggregation was measured by light transmittance aggregometry (LTA) following stimulation by adenosine diphosphate (ADP), collagen, and thrombin receptor activating peptide (TRAP) and by the point of care assay, VerifyNow which measures aspirin and thienopyridine reaction units. RESULTS: In-stent tissue protrusion with maximum projection area of ≥1 mm(2) was detected by optical coherence tomography (OCT) in 10/28 (36%) patients. Baseline characteristics were not significantly different between the two in-stent size groups (i.e., ≥1 mm(2) vs. <1 mm(2)) but after stimulation by collagen at 10 and 20 μg/ml, platelet reactivity as measured by LTA was significantly higher in the ≥1 mm(2) group compared with the <1 mm(2) group. No other differences in platelet function were detected. CONCLUSIONS: Collagen-induced platelet reactivity was related to in-stent tissue protrusion size following CAS. |
format | Online Article Text |
id | pubmed-5991223 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-59912232018-06-13 Optimal platelet function test for in-stent tissue protrusion following carotid artery stenting Tsujimoto, Masanori Enomoto, Yukiko Miyai, Masafumi Egashira, Yusuke Iwama, Toru J Int Med Res Clinical Reports PURPOSE: To determine the best platelet function test for in-stent tissue protrusion following carotid artery stenting (CAS). METHODS: Patients who underwent CAS were recruited prospectively in this observational study. Combination of aspirin 100 mg/day and clopidogrel 75 mg/day was administered for a minimum of 7 days prior to procedure. Platelet aggregation was measured by light transmittance aggregometry (LTA) following stimulation by adenosine diphosphate (ADP), collagen, and thrombin receptor activating peptide (TRAP) and by the point of care assay, VerifyNow which measures aspirin and thienopyridine reaction units. RESULTS: In-stent tissue protrusion with maximum projection area of ≥1 mm(2) was detected by optical coherence tomography (OCT) in 10/28 (36%) patients. Baseline characteristics were not significantly different between the two in-stent size groups (i.e., ≥1 mm(2) vs. <1 mm(2)) but after stimulation by collagen at 10 and 20 μg/ml, platelet reactivity as measured by LTA was significantly higher in the ≥1 mm(2) group compared with the <1 mm(2) group. No other differences in platelet function were detected. CONCLUSIONS: Collagen-induced platelet reactivity was related to in-stent tissue protrusion size following CAS. SAGE Publications 2018-03-19 2018-05 /pmc/articles/PMC5991223/ /pubmed/29552932 http://dx.doi.org/10.1177/0300060518762949 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Clinical Reports Tsujimoto, Masanori Enomoto, Yukiko Miyai, Masafumi Egashira, Yusuke Iwama, Toru Optimal platelet function test for in-stent tissue protrusion following carotid artery stenting |
title | Optimal platelet function test for in-stent tissue protrusion following carotid artery stenting |
title_full | Optimal platelet function test for in-stent tissue protrusion following carotid artery stenting |
title_fullStr | Optimal platelet function test for in-stent tissue protrusion following carotid artery stenting |
title_full_unstemmed | Optimal platelet function test for in-stent tissue protrusion following carotid artery stenting |
title_short | Optimal platelet function test for in-stent tissue protrusion following carotid artery stenting |
title_sort | optimal platelet function test for in-stent tissue protrusion following carotid artery stenting |
topic | Clinical Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991223/ https://www.ncbi.nlm.nih.gov/pubmed/29552932 http://dx.doi.org/10.1177/0300060518762949 |
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