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Optimal platelet function test for in-stent tissue protrusion following carotid artery stenting

PURPOSE: To determine the best platelet function test for in-stent tissue protrusion following carotid artery stenting (CAS). METHODS: Patients who underwent CAS were recruited prospectively in this observational study. Combination of aspirin 100 mg/day and clopidogrel 75 mg/day was administered for...

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Autores principales: Tsujimoto, Masanori, Enomoto, Yukiko, Miyai, Masafumi, Egashira, Yusuke, Iwama, Toru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991223/
https://www.ncbi.nlm.nih.gov/pubmed/29552932
http://dx.doi.org/10.1177/0300060518762949
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author Tsujimoto, Masanori
Enomoto, Yukiko
Miyai, Masafumi
Egashira, Yusuke
Iwama, Toru
author_facet Tsujimoto, Masanori
Enomoto, Yukiko
Miyai, Masafumi
Egashira, Yusuke
Iwama, Toru
author_sort Tsujimoto, Masanori
collection PubMed
description PURPOSE: To determine the best platelet function test for in-stent tissue protrusion following carotid artery stenting (CAS). METHODS: Patients who underwent CAS were recruited prospectively in this observational study. Combination of aspirin 100 mg/day and clopidogrel 75 mg/day was administered for a minimum of 7 days prior to procedure. Platelet aggregation was measured by light transmittance aggregometry (LTA) following stimulation by adenosine diphosphate (ADP), collagen, and thrombin receptor activating peptide (TRAP) and by the point of care assay, VerifyNow which measures aspirin and thienopyridine reaction units. RESULTS: In-stent tissue protrusion with maximum projection area of ≥1 mm(2) was detected by optical coherence tomography (OCT) in 10/28 (36%) patients. Baseline characteristics were not significantly different between the two in-stent size groups (i.e., ≥1 mm(2) vs. <1 mm(2)) but after stimulation by collagen at 10 and 20 μg/ml, platelet reactivity as measured by LTA was significantly higher in the ≥1 mm(2) group compared with the <1 mm(2) group. No other differences in platelet function were detected. CONCLUSIONS: Collagen-induced platelet reactivity was related to in-stent tissue protrusion size following CAS.
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spelling pubmed-59912232018-06-13 Optimal platelet function test for in-stent tissue protrusion following carotid artery stenting Tsujimoto, Masanori Enomoto, Yukiko Miyai, Masafumi Egashira, Yusuke Iwama, Toru J Int Med Res Clinical Reports PURPOSE: To determine the best platelet function test for in-stent tissue protrusion following carotid artery stenting (CAS). METHODS: Patients who underwent CAS were recruited prospectively in this observational study. Combination of aspirin 100 mg/day and clopidogrel 75 mg/day was administered for a minimum of 7 days prior to procedure. Platelet aggregation was measured by light transmittance aggregometry (LTA) following stimulation by adenosine diphosphate (ADP), collagen, and thrombin receptor activating peptide (TRAP) and by the point of care assay, VerifyNow which measures aspirin and thienopyridine reaction units. RESULTS: In-stent tissue protrusion with maximum projection area of ≥1 mm(2) was detected by optical coherence tomography (OCT) in 10/28 (36%) patients. Baseline characteristics were not significantly different between the two in-stent size groups (i.e., ≥1 mm(2) vs. <1 mm(2)) but after stimulation by collagen at 10 and 20 μg/ml, platelet reactivity as measured by LTA was significantly higher in the ≥1 mm(2) group compared with the <1 mm(2) group. No other differences in platelet function were detected. CONCLUSIONS: Collagen-induced platelet reactivity was related to in-stent tissue protrusion size following CAS. SAGE Publications 2018-03-19 2018-05 /pmc/articles/PMC5991223/ /pubmed/29552932 http://dx.doi.org/10.1177/0300060518762949 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Clinical Reports
Tsujimoto, Masanori
Enomoto, Yukiko
Miyai, Masafumi
Egashira, Yusuke
Iwama, Toru
Optimal platelet function test for in-stent tissue protrusion following carotid artery stenting
title Optimal platelet function test for in-stent tissue protrusion following carotid artery stenting
title_full Optimal platelet function test for in-stent tissue protrusion following carotid artery stenting
title_fullStr Optimal platelet function test for in-stent tissue protrusion following carotid artery stenting
title_full_unstemmed Optimal platelet function test for in-stent tissue protrusion following carotid artery stenting
title_short Optimal platelet function test for in-stent tissue protrusion following carotid artery stenting
title_sort optimal platelet function test for in-stent tissue protrusion following carotid artery stenting
topic Clinical Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991223/
https://www.ncbi.nlm.nih.gov/pubmed/29552932
http://dx.doi.org/10.1177/0300060518762949
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