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Role of quantitative analysis of T2 relaxation time in differentiating benign from malignant breast lesions
OBJECTIVE: To investigate the role of quantitative analysis of T2 relaxation time in the magnetic resonance imaging (MRI) diagnosis of breast cancer. METHODS: The study enrolled patients with clinical breast masses who were examined using MRI at eight different echo times. The differences in T2 rela...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991255/ https://www.ncbi.nlm.nih.gov/pubmed/29557239 http://dx.doi.org/10.1177/0300060517721071 |
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author | Liu, Li Yin, Bo Shek, Kawai Geng, Daoying Lu, Yiping Wen, Jianbo Kuai, Xinping Peng, Weijun |
author_facet | Liu, Li Yin, Bo Shek, Kawai Geng, Daoying Lu, Yiping Wen, Jianbo Kuai, Xinping Peng, Weijun |
author_sort | Liu, Li |
collection | PubMed |
description | OBJECTIVE: To investigate the role of quantitative analysis of T2 relaxation time in the magnetic resonance imaging (MRI) diagnosis of breast cancer. METHODS: The study enrolled patients with clinical breast masses who were examined using MRI at eight different echo times. The differences in T2 relaxation time of benign and malignant breast lesions were analysed. RESULTS: A total of 67 patients (67 breast lesions: 46 malignant, 21 benign) were examined. The mean ± SD T2 relaxation time was significantly lower in the 46 malignant lesions compared with the 21 benign lesions (82.69 ± 15.37 ms versus 95.48 ± 26.51 ms, respectively). The area under the curve was 0.731. Using 79.52 ms as the cut-off between benign and malignant breast lesions, a sensitivity of 85.7% and a specificity of 58.7% were obtained. CONCLUSIONS: There was a significant difference in T2 relaxation time between benign and malignant breast lesions. The specificity of using T2 relaxation time alone for the differentiation of benign from malignant lesions was not high, but it could constitute a new adjunct in the MRI diagnosis of breast cancer. |
format | Online Article Text |
id | pubmed-5991255 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-59912552018-06-13 Role of quantitative analysis of T2 relaxation time in differentiating benign from malignant breast lesions Liu, Li Yin, Bo Shek, Kawai Geng, Daoying Lu, Yiping Wen, Jianbo Kuai, Xinping Peng, Weijun J Int Med Res Clinical Reports OBJECTIVE: To investigate the role of quantitative analysis of T2 relaxation time in the magnetic resonance imaging (MRI) diagnosis of breast cancer. METHODS: The study enrolled patients with clinical breast masses who were examined using MRI at eight different echo times. The differences in T2 relaxation time of benign and malignant breast lesions were analysed. RESULTS: A total of 67 patients (67 breast lesions: 46 malignant, 21 benign) were examined. The mean ± SD T2 relaxation time was significantly lower in the 46 malignant lesions compared with the 21 benign lesions (82.69 ± 15.37 ms versus 95.48 ± 26.51 ms, respectively). The area under the curve was 0.731. Using 79.52 ms as the cut-off between benign and malignant breast lesions, a sensitivity of 85.7% and a specificity of 58.7% were obtained. CONCLUSIONS: There was a significant difference in T2 relaxation time between benign and malignant breast lesions. The specificity of using T2 relaxation time alone for the differentiation of benign from malignant lesions was not high, but it could constitute a new adjunct in the MRI diagnosis of breast cancer. SAGE Publications 2018-03-20 2018-05 /pmc/articles/PMC5991255/ /pubmed/29557239 http://dx.doi.org/10.1177/0300060517721071 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Clinical Reports Liu, Li Yin, Bo Shek, Kawai Geng, Daoying Lu, Yiping Wen, Jianbo Kuai, Xinping Peng, Weijun Role of quantitative analysis of T2 relaxation time in differentiating benign from malignant breast lesions |
title | Role of quantitative analysis of T2 relaxation time in differentiating benign from malignant breast lesions |
title_full | Role of quantitative analysis of T2 relaxation time in differentiating benign from malignant breast lesions |
title_fullStr | Role of quantitative analysis of T2 relaxation time in differentiating benign from malignant breast lesions |
title_full_unstemmed | Role of quantitative analysis of T2 relaxation time in differentiating benign from malignant breast lesions |
title_short | Role of quantitative analysis of T2 relaxation time in differentiating benign from malignant breast lesions |
title_sort | role of quantitative analysis of t2 relaxation time in differentiating benign from malignant breast lesions |
topic | Clinical Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991255/ https://www.ncbi.nlm.nih.gov/pubmed/29557239 http://dx.doi.org/10.1177/0300060517721071 |
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