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Interactions between stress and physical activity on Alzheimer's disease pathology

Physical activity and stress are both environmental modifiers of Alzheimer's disease (AD) risk. Animal studies of physical activity in AD models have largely reported positive results, however benefits are not always observed in either cognitive or pathological outcomes and inconsistencies amon...

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Autores principales: Yuede, Carla M., Timson, Benjamin F., Hettinger, Jane C., Yuede, Kayla M., Edwards, Hannah M., Lawson, Justin E., Zimmerman, Scott D., Cirrito, John R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991353/
https://www.ncbi.nlm.nih.gov/pubmed/29888311
http://dx.doi.org/10.1016/j.ynstr.2018.02.004
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author Yuede, Carla M.
Timson, Benjamin F.
Hettinger, Jane C.
Yuede, Kayla M.
Edwards, Hannah M.
Lawson, Justin E.
Zimmerman, Scott D.
Cirrito, John R.
author_facet Yuede, Carla M.
Timson, Benjamin F.
Hettinger, Jane C.
Yuede, Kayla M.
Edwards, Hannah M.
Lawson, Justin E.
Zimmerman, Scott D.
Cirrito, John R.
author_sort Yuede, Carla M.
collection PubMed
description Physical activity and stress are both environmental modifiers of Alzheimer's disease (AD) risk. Animal studies of physical activity in AD models have largely reported positive results, however benefits are not always observed in either cognitive or pathological outcomes and inconsistencies among findings remain. Studies using forced exercise may increase stress and mitigate some of the benefit of physical activity in AD models, while voluntary exercise regimens may not achieve optimal intensity to provide robust benefit. We evaluated the findings of studies of voluntary and forced exercise regimens in AD mouse models to determine the influence of stress, or the intensity of exercise needed to outweigh the negative effects of stress on AD measures. In addition, we show that chronic physical activity in a mouse model of AD can prevent the effects of acute restraint stress on Aβ levels in the hippocampus. Stress and physical activity have many overlapping and divergent effects on the body and some of the possible mechanisms through which physical activity may protect against stress-induced risk factors for AD are discussed. While the physiological effects of acute stress and acute exercise overlap, chronic effects of physical activity appear to directly oppose the effects of chronic stress on risk factors for AD. Further study is needed to identify optimal parameters for intensity, duration and frequency of physical activity to counterbalance effects of stress on the development and progression of AD.
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spelling pubmed-59913532018-06-08 Interactions between stress and physical activity on Alzheimer's disease pathology Yuede, Carla M. Timson, Benjamin F. Hettinger, Jane C. Yuede, Kayla M. Edwards, Hannah M. Lawson, Justin E. Zimmerman, Scott D. Cirrito, John R. Neurobiol Stress Article from the Special Issue on "Stress and the Pathogenesis of Alzheimer’s Disease"; Edited by Hongxin Dong, John Csernansky Physical activity and stress are both environmental modifiers of Alzheimer's disease (AD) risk. Animal studies of physical activity in AD models have largely reported positive results, however benefits are not always observed in either cognitive or pathological outcomes and inconsistencies among findings remain. Studies using forced exercise may increase stress and mitigate some of the benefit of physical activity in AD models, while voluntary exercise regimens may not achieve optimal intensity to provide robust benefit. We evaluated the findings of studies of voluntary and forced exercise regimens in AD mouse models to determine the influence of stress, or the intensity of exercise needed to outweigh the negative effects of stress on AD measures. In addition, we show that chronic physical activity in a mouse model of AD can prevent the effects of acute restraint stress on Aβ levels in the hippocampus. Stress and physical activity have many overlapping and divergent effects on the body and some of the possible mechanisms through which physical activity may protect against stress-induced risk factors for AD are discussed. While the physiological effects of acute stress and acute exercise overlap, chronic effects of physical activity appear to directly oppose the effects of chronic stress on risk factors for AD. Further study is needed to identify optimal parameters for intensity, duration and frequency of physical activity to counterbalance effects of stress on the development and progression of AD. Elsevier 2018-02-22 /pmc/articles/PMC5991353/ /pubmed/29888311 http://dx.doi.org/10.1016/j.ynstr.2018.02.004 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article from the Special Issue on "Stress and the Pathogenesis of Alzheimer’s Disease"; Edited by Hongxin Dong, John Csernansky
Yuede, Carla M.
Timson, Benjamin F.
Hettinger, Jane C.
Yuede, Kayla M.
Edwards, Hannah M.
Lawson, Justin E.
Zimmerman, Scott D.
Cirrito, John R.
Interactions between stress and physical activity on Alzheimer's disease pathology
title Interactions between stress and physical activity on Alzheimer's disease pathology
title_full Interactions between stress and physical activity on Alzheimer's disease pathology
title_fullStr Interactions between stress and physical activity on Alzheimer's disease pathology
title_full_unstemmed Interactions between stress and physical activity on Alzheimer's disease pathology
title_short Interactions between stress and physical activity on Alzheimer's disease pathology
title_sort interactions between stress and physical activity on alzheimer's disease pathology
topic Article from the Special Issue on "Stress and the Pathogenesis of Alzheimer’s Disease"; Edited by Hongxin Dong, John Csernansky
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991353/
https://www.ncbi.nlm.nih.gov/pubmed/29888311
http://dx.doi.org/10.1016/j.ynstr.2018.02.004
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