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Video-fluoroscopic swallowing study scale for predicting aspiration pneumonia in Parkinson’s disease
INTRODUCTION: A number of video-fluoroscopic swallowing study (VFSS) abnormalities have been reported in patients with Parkinson’s disease (PD). However, the most crucial finding of subsequent aspiration pneumonia has not been validated fully. We conducted a retrospective and case-control study to d...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991364/ https://www.ncbi.nlm.nih.gov/pubmed/29874285 http://dx.doi.org/10.1371/journal.pone.0197608 |
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author | Tomita, Satoshi Oeda, Tomoko Umemura, Atsushi Kohsaka, Masayuki Park, Kwiyoung Yamamoto, Kenji Sugiyama, Hiroshi Sawada, Hideyuki |
author_facet | Tomita, Satoshi Oeda, Tomoko Umemura, Atsushi Kohsaka, Masayuki Park, Kwiyoung Yamamoto, Kenji Sugiyama, Hiroshi Sawada, Hideyuki |
author_sort | Tomita, Satoshi |
collection | PubMed |
description | INTRODUCTION: A number of video-fluoroscopic swallowing study (VFSS) abnormalities have been reported in patients with Parkinson’s disease (PD). However, the most crucial finding of subsequent aspiration pneumonia has not been validated fully. We conducted a retrospective and case-control study to determine the clinically significant VFSS findings in this population, and to propose a practical scale for predicting aspiration pneumonia in patients with PD. METHODS: We enrolled 184 PD patients who underwent VFSS because of suspected dysphagia. The patients who developed aspiration pneumonia within six months of the VFSS were assigned as cases and the patients without aspiration pneumonia at six months were designated as controls. Logistic regression analysis was performed to determine the prognostic VFSS features based on the data of swallowing 3 mL of jelly, which were used to make a PD VFSS scale (PDVFS). The validity of the new PDVFS was evaluated by ROC analysis. Additionally, we used the survival time analysis to compare time to death between groups, stratified by the PDVFS score. RESULTS: Twenty-five patients developed aspiration pneumonia. Among the previously-proposed VFSS features, mastication, lingual motility prior to transfer, aspiration, and total swallow time were identified as significant prognostic factors. We combined these factors to form the PDVFS. The PDVFS score ranges from 0 to 12, with 12 being the worst. ROC analysis revealed 92% sensitivity and 82% specificity at a cutoff point of 3. The higher PDVFS group showed shorter time-to-death than the lower PDVFS group (log rank P = 0.001). CONCLUSION: Our newly developed VFSS severity scale (based on jelly swallowing) for patients with PD was easy to rate and could predict subsequent aspiration pneumonia and poor prognosis in patients with PD. |
format | Online Article Text |
id | pubmed-5991364 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-59913642018-06-08 Video-fluoroscopic swallowing study scale for predicting aspiration pneumonia in Parkinson’s disease Tomita, Satoshi Oeda, Tomoko Umemura, Atsushi Kohsaka, Masayuki Park, Kwiyoung Yamamoto, Kenji Sugiyama, Hiroshi Sawada, Hideyuki PLoS One Research Article INTRODUCTION: A number of video-fluoroscopic swallowing study (VFSS) abnormalities have been reported in patients with Parkinson’s disease (PD). However, the most crucial finding of subsequent aspiration pneumonia has not been validated fully. We conducted a retrospective and case-control study to determine the clinically significant VFSS findings in this population, and to propose a practical scale for predicting aspiration pneumonia in patients with PD. METHODS: We enrolled 184 PD patients who underwent VFSS because of suspected dysphagia. The patients who developed aspiration pneumonia within six months of the VFSS were assigned as cases and the patients without aspiration pneumonia at six months were designated as controls. Logistic regression analysis was performed to determine the prognostic VFSS features based on the data of swallowing 3 mL of jelly, which were used to make a PD VFSS scale (PDVFS). The validity of the new PDVFS was evaluated by ROC analysis. Additionally, we used the survival time analysis to compare time to death between groups, stratified by the PDVFS score. RESULTS: Twenty-five patients developed aspiration pneumonia. Among the previously-proposed VFSS features, mastication, lingual motility prior to transfer, aspiration, and total swallow time were identified as significant prognostic factors. We combined these factors to form the PDVFS. The PDVFS score ranges from 0 to 12, with 12 being the worst. ROC analysis revealed 92% sensitivity and 82% specificity at a cutoff point of 3. The higher PDVFS group showed shorter time-to-death than the lower PDVFS group (log rank P = 0.001). CONCLUSION: Our newly developed VFSS severity scale (based on jelly swallowing) for patients with PD was easy to rate and could predict subsequent aspiration pneumonia and poor prognosis in patients with PD. Public Library of Science 2018-06-06 /pmc/articles/PMC5991364/ /pubmed/29874285 http://dx.doi.org/10.1371/journal.pone.0197608 Text en © 2018 Tomita et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Tomita, Satoshi Oeda, Tomoko Umemura, Atsushi Kohsaka, Masayuki Park, Kwiyoung Yamamoto, Kenji Sugiyama, Hiroshi Sawada, Hideyuki Video-fluoroscopic swallowing study scale for predicting aspiration pneumonia in Parkinson’s disease |
title | Video-fluoroscopic swallowing study scale for predicting aspiration pneumonia in Parkinson’s disease |
title_full | Video-fluoroscopic swallowing study scale for predicting aspiration pneumonia in Parkinson’s disease |
title_fullStr | Video-fluoroscopic swallowing study scale for predicting aspiration pneumonia in Parkinson’s disease |
title_full_unstemmed | Video-fluoroscopic swallowing study scale for predicting aspiration pneumonia in Parkinson’s disease |
title_short | Video-fluoroscopic swallowing study scale for predicting aspiration pneumonia in Parkinson’s disease |
title_sort | video-fluoroscopic swallowing study scale for predicting aspiration pneumonia in parkinson’s disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991364/ https://www.ncbi.nlm.nih.gov/pubmed/29874285 http://dx.doi.org/10.1371/journal.pone.0197608 |
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