Dissecting an adiposity locus with an arsenal of genomics

We discuss a recent study that has identified and validated the link between a type-2 diabetes (T2D) association and human adipose biology by means of KLF14 gene expression. In addition to being maternally imprinted, the contributed risk at this locus is greater in female carriers.

Detalles Bibliográficos
Autores principales: Lorenz, Kim, Voight, Benjamin F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991457/
https://www.ncbi.nlm.nih.gov/pubmed/29880058
http://dx.doi.org/10.1186/s13059-018-1460-y
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author Lorenz, Kim
Voight, Benjamin F.
author_facet Lorenz, Kim
Voight, Benjamin F.
author_sort Lorenz, Kim
collection PubMed
description We discuss a recent study that has identified and validated the link between a type-2 diabetes (T2D) association and human adipose biology by means of KLF14 gene expression. In addition to being maternally imprinted, the contributed risk at this locus is greater in female carriers.
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spelling pubmed-59914572018-06-21 Dissecting an adiposity locus with an arsenal of genomics Lorenz, Kim Voight, Benjamin F. Genome Biol Research Highlight We discuss a recent study that has identified and validated the link between a type-2 diabetes (T2D) association and human adipose biology by means of KLF14 gene expression. In addition to being maternally imprinted, the contributed risk at this locus is greater in female carriers. BioMed Central 2018-06-07 /pmc/articles/PMC5991457/ /pubmed/29880058 http://dx.doi.org/10.1186/s13059-018-1460-y Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Highlight
Lorenz, Kim
Voight, Benjamin F.
Dissecting an adiposity locus with an arsenal of genomics
title Dissecting an adiposity locus with an arsenal of genomics
title_full Dissecting an adiposity locus with an arsenal of genomics
title_fullStr Dissecting an adiposity locus with an arsenal of genomics
title_full_unstemmed Dissecting an adiposity locus with an arsenal of genomics
title_short Dissecting an adiposity locus with an arsenal of genomics
title_sort dissecting an adiposity locus with an arsenal of genomics
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991457/
https://www.ncbi.nlm.nih.gov/pubmed/29880058
http://dx.doi.org/10.1186/s13059-018-1460-y
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