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The peopling of South America and the trans-Andean gene flow of the first settlers
Genetic and archaeological data indicate that the initial Paleoindian settlers of South America followed two entry routes separated by the Andes and the Amazon rainforest. The interactions between these paths and their impact on the peopling of South America remain unclear. Analysis of genetic varia...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991523/ https://www.ncbi.nlm.nih.gov/pubmed/29735605 http://dx.doi.org/10.1101/gr.234674.118 |
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author | Gómez-Carballa, Alberto Pardo-Seco, Jacobo Brandini, Stefania Achilli, Alessandro Perego, Ugo A. Coble, Michael D. Diegoli, Toni M. Álvarez-Iglesias, Vanesa Martinón-Torres, Federico Olivieri, Anna Torroni, Antonio Salas, Antonio |
author_facet | Gómez-Carballa, Alberto Pardo-Seco, Jacobo Brandini, Stefania Achilli, Alessandro Perego, Ugo A. Coble, Michael D. Diegoli, Toni M. Álvarez-Iglesias, Vanesa Martinón-Torres, Federico Olivieri, Anna Torroni, Antonio Salas, Antonio |
author_sort | Gómez-Carballa, Alberto |
collection | PubMed |
description | Genetic and archaeological data indicate that the initial Paleoindian settlers of South America followed two entry routes separated by the Andes and the Amazon rainforest. The interactions between these paths and their impact on the peopling of South America remain unclear. Analysis of genetic variation in the Peruvian Andes and regions located south of the Amazon River might provide clues on this issue. We analyzed mitochondrial DNA variation at different Andean locations and >360,000 autosomal SNPs from 28 Native American ethnic groups to evaluate different trans-Andean demographic scenarios. Our data reveal that the Peruvian Altiplano was an important enclave for early Paleoindian expansions and point to a genetic continuity in the Andes until recent times, which was only marginally affected by gene flow from the Amazonian lowlands. Genomic variation shows a good fit with the archaeological evidence, indicating that the genetic interactions between the descendants of the settlers that followed the Pacific and Atlantic routes were extremely limited. |
format | Online Article Text |
id | pubmed-5991523 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-59915232018-12-01 The peopling of South America and the trans-Andean gene flow of the first settlers Gómez-Carballa, Alberto Pardo-Seco, Jacobo Brandini, Stefania Achilli, Alessandro Perego, Ugo A. Coble, Michael D. Diegoli, Toni M. Álvarez-Iglesias, Vanesa Martinón-Torres, Federico Olivieri, Anna Torroni, Antonio Salas, Antonio Genome Res Research Genetic and archaeological data indicate that the initial Paleoindian settlers of South America followed two entry routes separated by the Andes and the Amazon rainforest. The interactions between these paths and their impact on the peopling of South America remain unclear. Analysis of genetic variation in the Peruvian Andes and regions located south of the Amazon River might provide clues on this issue. We analyzed mitochondrial DNA variation at different Andean locations and >360,000 autosomal SNPs from 28 Native American ethnic groups to evaluate different trans-Andean demographic scenarios. Our data reveal that the Peruvian Altiplano was an important enclave for early Paleoindian expansions and point to a genetic continuity in the Andes until recent times, which was only marginally affected by gene flow from the Amazonian lowlands. Genomic variation shows a good fit with the archaeological evidence, indicating that the genetic interactions between the descendants of the settlers that followed the Pacific and Atlantic routes were extremely limited. Cold Spring Harbor Laboratory Press 2018-06 /pmc/articles/PMC5991523/ /pubmed/29735605 http://dx.doi.org/10.1101/gr.234674.118 Text en © 2018 Gómez-Carballa et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Research Gómez-Carballa, Alberto Pardo-Seco, Jacobo Brandini, Stefania Achilli, Alessandro Perego, Ugo A. Coble, Michael D. Diegoli, Toni M. Álvarez-Iglesias, Vanesa Martinón-Torres, Federico Olivieri, Anna Torroni, Antonio Salas, Antonio The peopling of South America and the trans-Andean gene flow of the first settlers |
title | The peopling of South America and the trans-Andean gene flow of the first settlers |
title_full | The peopling of South America and the trans-Andean gene flow of the first settlers |
title_fullStr | The peopling of South America and the trans-Andean gene flow of the first settlers |
title_full_unstemmed | The peopling of South America and the trans-Andean gene flow of the first settlers |
title_short | The peopling of South America and the trans-Andean gene flow of the first settlers |
title_sort | peopling of south america and the trans-andean gene flow of the first settlers |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991523/ https://www.ncbi.nlm.nih.gov/pubmed/29735605 http://dx.doi.org/10.1101/gr.234674.118 |
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