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The peopling of South America and the trans-Andean gene flow of the first settlers

Genetic and archaeological data indicate that the initial Paleoindian settlers of South America followed two entry routes separated by the Andes and the Amazon rainforest. The interactions between these paths and their impact on the peopling of South America remain unclear. Analysis of genetic varia...

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Autores principales: Gómez-Carballa, Alberto, Pardo-Seco, Jacobo, Brandini, Stefania, Achilli, Alessandro, Perego, Ugo A., Coble, Michael D., Diegoli, Toni M., Álvarez-Iglesias, Vanesa, Martinón-Torres, Federico, Olivieri, Anna, Torroni, Antonio, Salas, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991523/
https://www.ncbi.nlm.nih.gov/pubmed/29735605
http://dx.doi.org/10.1101/gr.234674.118
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author Gómez-Carballa, Alberto
Pardo-Seco, Jacobo
Brandini, Stefania
Achilli, Alessandro
Perego, Ugo A.
Coble, Michael D.
Diegoli, Toni M.
Álvarez-Iglesias, Vanesa
Martinón-Torres, Federico
Olivieri, Anna
Torroni, Antonio
Salas, Antonio
author_facet Gómez-Carballa, Alberto
Pardo-Seco, Jacobo
Brandini, Stefania
Achilli, Alessandro
Perego, Ugo A.
Coble, Michael D.
Diegoli, Toni M.
Álvarez-Iglesias, Vanesa
Martinón-Torres, Federico
Olivieri, Anna
Torroni, Antonio
Salas, Antonio
author_sort Gómez-Carballa, Alberto
collection PubMed
description Genetic and archaeological data indicate that the initial Paleoindian settlers of South America followed two entry routes separated by the Andes and the Amazon rainforest. The interactions between these paths and their impact on the peopling of South America remain unclear. Analysis of genetic variation in the Peruvian Andes and regions located south of the Amazon River might provide clues on this issue. We analyzed mitochondrial DNA variation at different Andean locations and >360,000 autosomal SNPs from 28 Native American ethnic groups to evaluate different trans-Andean demographic scenarios. Our data reveal that the Peruvian Altiplano was an important enclave for early Paleoindian expansions and point to a genetic continuity in the Andes until recent times, which was only marginally affected by gene flow from the Amazonian lowlands. Genomic variation shows a good fit with the archaeological evidence, indicating that the genetic interactions between the descendants of the settlers that followed the Pacific and Atlantic routes were extremely limited.
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spelling pubmed-59915232018-12-01 The peopling of South America and the trans-Andean gene flow of the first settlers Gómez-Carballa, Alberto Pardo-Seco, Jacobo Brandini, Stefania Achilli, Alessandro Perego, Ugo A. Coble, Michael D. Diegoli, Toni M. Álvarez-Iglesias, Vanesa Martinón-Torres, Federico Olivieri, Anna Torroni, Antonio Salas, Antonio Genome Res Research Genetic and archaeological data indicate that the initial Paleoindian settlers of South America followed two entry routes separated by the Andes and the Amazon rainforest. The interactions between these paths and their impact on the peopling of South America remain unclear. Analysis of genetic variation in the Peruvian Andes and regions located south of the Amazon River might provide clues on this issue. We analyzed mitochondrial DNA variation at different Andean locations and >360,000 autosomal SNPs from 28 Native American ethnic groups to evaluate different trans-Andean demographic scenarios. Our data reveal that the Peruvian Altiplano was an important enclave for early Paleoindian expansions and point to a genetic continuity in the Andes until recent times, which was only marginally affected by gene flow from the Amazonian lowlands. Genomic variation shows a good fit with the archaeological evidence, indicating that the genetic interactions between the descendants of the settlers that followed the Pacific and Atlantic routes were extremely limited. Cold Spring Harbor Laboratory Press 2018-06 /pmc/articles/PMC5991523/ /pubmed/29735605 http://dx.doi.org/10.1101/gr.234674.118 Text en © 2018 Gómez-Carballa et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Research
Gómez-Carballa, Alberto
Pardo-Seco, Jacobo
Brandini, Stefania
Achilli, Alessandro
Perego, Ugo A.
Coble, Michael D.
Diegoli, Toni M.
Álvarez-Iglesias, Vanesa
Martinón-Torres, Federico
Olivieri, Anna
Torroni, Antonio
Salas, Antonio
The peopling of South America and the trans-Andean gene flow of the first settlers
title The peopling of South America and the trans-Andean gene flow of the first settlers
title_full The peopling of South America and the trans-Andean gene flow of the first settlers
title_fullStr The peopling of South America and the trans-Andean gene flow of the first settlers
title_full_unstemmed The peopling of South America and the trans-Andean gene flow of the first settlers
title_short The peopling of South America and the trans-Andean gene flow of the first settlers
title_sort peopling of south america and the trans-andean gene flow of the first settlers
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991523/
https://www.ncbi.nlm.nih.gov/pubmed/29735605
http://dx.doi.org/10.1101/gr.234674.118
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