Loss of murine Gfi1 causes neutropenia and induces osteoporosis depending on the pathogen load and systemic inflammation

Gfi1 is a key molecule in hematopoietic lineage development and mutations in GFI1 cause severe congenital neutropenia (SCN). Neutropenia is associated with low bone mass, but the underlying mechanisms are poorly characterized. Using Gfi1 knock-out mice (Gfi1-ko/ko) as SCN model, we studied the relat...

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Detalles Bibliográficos
Autores principales: Geissler, Sven, Textor, Martin, Stumpp, Sabine, Seitz, Sebastian, Lekaj, Anja, Brunk, Sabrina, Klaassen, Sabine, Schinke, Thorsten, Klein, Christoph, Mundlos, Stefan, Kornak, Uwe, Kühnisch, Jirko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991660/
https://www.ncbi.nlm.nih.gov/pubmed/29879182
http://dx.doi.org/10.1371/journal.pone.0198510

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