Interrogation of transcriptomic changes associated with drug-induced hepatic sinusoidal dilatation in colorectal cancer

Drug-related sinusoidal dilatation (SD) is a common form of hepatotoxicity associated with oxaliplatin-based chemotherapy used prior to resection of colorectal liver metastases (CRLM). Recently, hepatic SD has also been associated with anti-delta like 4 (DLL4) cancer therapies targeting the NOTCH pa...

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Detalles Bibliográficos
Autores principales: Jarzabek, Monika A., Proctor, William R., Vogt, Jennifer, Desai, Rupal, Dicker, Patrick, Cain, Gary, Raja, Rajiv, Brodbeck, Jens, Stevens, Dale, van der Stok, Eric P., Martens, John W. M., Verhoef, Cornelis, Hegde, Priti S., Byrne, Annette T., Tarrant, Jacqueline M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991753/
https://www.ncbi.nlm.nih.gov/pubmed/29879147
http://dx.doi.org/10.1371/journal.pone.0198099

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