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Nuclear m(6)A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development

The N(6)-methyladenosine (m(6)A) modification is the most prevalent internal RNA modification in eukaryotes. The majority of m(6)A sites are found in the last exon and 3’ UTRs. Here we show that the nuclear m(6)A reader YTHDC1 is essential for embryo viability and germline development in mouse. Spec...

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Detalles Bibliográficos
Autores principales:	Kasowitz, Seth D., Ma, Jun, Anderson, Stephen J., Leu, N. Adrian, Xu, Yang, Gregory, Brian D., Schultz, Richard M., Wang, P. Jeremy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991768/ https://www.ncbi.nlm.nih.gov/pubmed/29799838 http://dx.doi.org/10.1371/journal.pgen.1007412

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