Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning

Cyanide is a potent toxic agent, and the few available antidotes are not amenable to rapid deployment in mass exposures. As a result, there are ongoing efforts to exploit different animal models to identify novel countermeasures. We have created a pipeline that combines high-throughput screening in...

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Detalles Bibliográficos
Autores principales: Sips, Patrick Y., Shi, Xu, Musso, Gabriel, Nath, Anjali K., Zhao, Yanbin, Nielson, Jason, Morningstar, Jordan, Kelly, Amy E., Mikell, Brittney, Buys, Eva, Bebarta, Vikhyat, Rutter, Jared, Davisson, V. Jo, Mahon, Sari, Brenner, Matthew, Boss, Gerry R., Peterson, Randall T., Gerszten, Robert E., MacRae, Calum A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991913/
https://www.ncbi.nlm.nih.gov/pubmed/29879736
http://dx.doi.org/10.1371/journal.pone.0193889

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