Disruption of the beclin 1/Bcl-2 autophagy regulatory complex promotes longevity in mice

Autophagy increases lifespan of model organisms; however, its role in promoting mammalian longevity is less well-established(1,2). Here, we report lifespan and healthspan extension in a mouse model with increased basal autophagy. To determine the effects of constitutively increased autophagy on mamm...

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Detalles Bibliográficos
Autores principales: Fernández, Álvaro F., Sebti, Salwa, Wei, Yongjie, Zou, Zhongju, Shi, Mingjun, McMillan, Kathryn L., He, Congcong, Ting, Tabitha, Liu, Yang, Chiang, Wei-Chung, Marciano, Denise K., Schiattarella, Gabriele G., Bhagat, Govind, Moe, Orson W., Hu, Ming Chang, Levine, Beth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992097/
https://www.ncbi.nlm.nih.gov/pubmed/29849149
http://dx.doi.org/10.1038/s41586-018-0162-7

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