Cargando…

Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins

Signal transduction cascades governed by kinases and GTPases are a critical component of the command and control of cellular processes, with the precise outcome partly determined by direct protein–protein interactions (PPIs). Here, we use the human ROCO proteins as a model for investigating PPI sign...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tomkins, James E., Dihanich, Sybille, Beilina, Alexandra, Ferrari, Raffaele, Ilacqua, Nicolò, Cookson, Mark R., Lewis, Patrick A., Manzoni, Claudia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992104/ https://www.ncbi.nlm.nih.gov/pubmed/29513927 http://dx.doi.org/10.1002/pmic.201700444

Ejemplares similares

GTP binding controls complex formation by the human ROCO protein MASL1
por: Dihanich, Sybille, et al.
Publicado: (2014)

Roco Proteins and the Parkinson’s Disease-Associated LRRK2
por: Liao, Jingling, et al.
Publicado: (2018)

Roco Proteins: GTPases with a Baroque Structure and Mechanism
por: Wauters, Lina, et al.
Publicado: (2019)

The LRRK2-related Roco kinase Roco2 is regulated by Rab1A and controls the actin cytoskeleton
por: Kicka, Sebastian, et al.
Publicado: (2011)

GTP binding and intramolecular regulation by the ROC domain of Death Associated Protein Kinase 1
por: Jebelli, Joseph D., et al.
Publicado: (2012)

A Conserved Role for LRRK2 and Roco Proteins in the Regulation of Mitochondrial Activity
por: Rosenbusch, Katharina E., et al.
Publicado: (2021)

Genetic, Structural, and Molecular Insights into the Function of Ras of Complex Proteins Domains
por: Civiero, Laura, et al.
Publicado: (2014)

PINOT: an intuitive resource for integrating protein-protein interactions
por: Tomkins, James E., et al.
Publicado: (2020)

Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases()
por: Mamais, Adamantios, et al.
Publicado: (2013)

Stratification of candidate genes for Parkinson’s disease using weighted protein-protein interaction network analysis
por: Ferrari, Raffaele, et al.
Publicado: (2018)

LRRK 2 gene mutations in the pathophysiology of the ROCO domain and therapeutic targets for Parkinson’s disease: a review
por: Chen, Meng-Ling, et al.
Publicado: (2018)

mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1
por: Manzoni, Claudia, et al.
Publicado: (2016)

mTOR independent alteration in ULK1 Ser758 phosphorylation following chronic LRRK2 kinase inhibition
por: Manzoni, Claudia, et al.
Publicado: (2018)

Weighted Protein Interaction Network Analysis of Frontotemporal Dementia
por: Ferrari, Raffaele, et al.
Publicado: (2016)

Inhibition of LRRK2 kinase activity stimulates macroautophagy()
por: Manzoni, Claudia, et al.
Publicado: (2013)

MRG Proteins Are Shared by Multiple Protein Complexes With Distinct Functions
por: Devoucoux, Maëva, et al.
Publicado: (2022)

Lysosomal positioning regulates Rab10 phosphorylation at LRRK2(+) lysosomes
por: Kluss, Jillian H., et al.
Publicado: (2022)

Integrating protein networks and machine learning for disease stratification in the Hereditary Spastic Paraplegias
por: Vavouraki, Nikoleta, et al.
Publicado: (2021)

Arsenite Stress Down-regulates Phosphorylation and 14-3-3 Binding of Leucine-rich Repeat Kinase 2 (LRRK2), Promoting Self-association and Cellular Redistribution
por: Mamais, Adamantios, et al.
Publicado: (2014)

Protein Localization at Mitochondria-ER Contact Sites in Basal and Stress Conditions
por: Ilacqua, Nicolò, et al.
Publicado: (2017)

Generation of iPSC line from a Parkinson patient with PARK7 mutation and CRISPR-edited Gibco human episomal iPSC line to mimic PARK7 mutation
por: Mazza, Melissa Conti, et al.
Publicado: (2021)

The Parkinson's Disease Associated LRRK2 Exhibits Weaker In Vitro Phosphorylation of 4E-BP Compared to Autophosphorylation
por: Kumar, Azad, et al.
Publicado: (2010)

Cell population-specific expression analysis of human cerebellum
por: Kuhn, Alexandre, et al.
Publicado: (2012)

The LRRK2 signalling system
por: Price, Alice, et al.
Publicado: (2018)

Analysis of macroautophagy related proteins in G2019S LRRK2 Parkinson’s disease brains with Lewy body pathology
por: Mamais, Adamantios, et al.
Publicado: (2018)

Isolation and analysis of fractions enriched in WrappER-associated mitochondria from mouse liver
por: Ilacqua, Nicolò, et al.
Publicado: (2021)

Measuring Lactase Enzymatic Activity in the Teaching Lab
por: Leksmono, Cattleya S., et al.
Publicado: (2018)

Mitochondrial Alterations in PINK1 Deficient Cells Are Influenced by Calcineurin-Dependent Dephosphorylation of Dynamin-Related Protein 1
por: Sandebring, Anna, et al.
Publicado: (2009)

Pathogenic Parkinson’s disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation()
por: Manzoni, Claudia, et al.
Publicado: (2013)

Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice
por: Pellegrini, Laura, et al.
Publicado: (2018)

LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding
por: Taymans, Jean-Marc, et al.
Publicado: (2011)

Aurora-C Interactions with Survivin and INCENP Reveal Shared and Distinct Features Compared with Aurora-B Chromosome Passenger Protein Complex
por: Sasai, Kaori, et al.
Publicado: (2016)

Whole-genome screening identifies proteins localized to distinct nuclear bodies
por: Fong, Ka-wing, et al.
Publicado: (2013)

Identifying relationships between unrelated pharmaceutical target proteins on the basis of shared active compounds
por: Miljković, Filip, et al.
Publicado: (2017)

Rare variants in LRRK1 and Parkinson's disease
por: Schulte, Eva C., et al.
Publicado: (2013)

CERNBox - Link Share & Authenticated Share
por: Manzoni, Alex Marc, et al.
Publicado: (2017)

Distinction of subtype-specific antibodies against European porcine influenza viruses by indirect ELISA based on recombinant hemagglutinin protein fragment-1
por: Zhao, Na, et al.
Publicado: (2013)

Shared as well as distinct roles of EHD proteins revealed by biochemical and functional comparisons in mammalian cells and C. elegans
por: George, Manju, et al.
Publicado: (2007)

Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses
por: Kapeli, Katannya, et al.
Publicado: (2016)

Qlik sense: advanced data visualization for your organization : learning path : create smart data visualizations and predictive analytics solutions
por: Ilacqua, Christopher
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_6splc5t0h10otu61rjo8lr5pod