Cargando…

Transcriptional cofactors Ski and SnoN are major regulators of the TGF-β/Smad signaling pathway in health and disease

The transforming growth factor-β (TGF-β) family plays major pleiotropic roles by regulating many physiological processes in development and tissue homeostasis. The TGF-β signaling pathway outcome relies on the control of the spatial and temporal expression of >500 genes, which depend on the funct...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tecalco-Cruz, Angeles C., Ríos-López, Diana G., Vázquez-Victorio, Genaro, Rosales-Alvarez, Reyna E., Macías-Silva, Marina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992185/ https://www.ncbi.nlm.nih.gov/pubmed/29892481 http://dx.doi.org/10.1038/s41392-018-0015-8

Ejemplares similares

TGF-β Repressors SnoN and Ski Are Implicated in Human Colorectal Carcinogenesis
por: Bravou, Vasiliki, et al.
Publicado: (2009)

Efficient TGF-β/SMAD signaling in human melanoma cells associated with high c-SKI/SnoN expression
por: Javelaud, Delphine, et al.
Publicado: (2011)

TGF-β/SMAD canonical pathway induces the expression of transcriptional cofactor TAZ in liver cancer cells
por: Ríos-López, Diana G., et al.
Publicado: (2023)

SnoN Stabilizes the SMAD3/SMAD4 Protein Complex
por: Walldén, Karin, et al.
Publicado: (2017)

Arkadia-SKI/SnoN signaling differentially regulates TGF-β–induced iTreg and Th17 cell differentiation
por: Xu, Hao, et al.
Publicado: (2021)

SKIL/SnoN attenuates TGF-β1/SMAD signaling-dependent collagen synthesis in hepatic fibrosis
por: Chi, Cheng, et al.
Publicado: (2023)

Jiangtang Tongmai Prescription Reduced Diabetic Lung Injury Through SnoN and TGF-β1/Smads Signaling Pathway
por: Ding, Nian, et al.
Publicado: (2022)

SnoN facilitates ALK1–Smad1/5 signaling during embryonic angiogenesis
por: Zhu, Qingwei, et al.
Publicado: (2013)

Herbal compound 861 prevents hepatic fibrosis by inhibiting the TGF-β1/Smad/SnoN pathway in bile duct-ligated rats
por: Chi, Cheng, et al.
Publicado: (2018)

TGF-β signaling induces SnoN to suppress BMP-induced hypertrophic maturation of chondrocytes
por: Maeda, Shingo, et al.
Publicado: (2012)

Oxymatrine Inhibits Renal Tubular EMT Induced by High Glucose via Upregulation of SnoN and Inhibition of TGF-β1/Smad Signaling Pathway
por: Liu, Lirong, et al.
Publicado: (2016)

SnoN upregulation ameliorates renal fibrosis in diabetic nephropathy
por: Liu, Lirong, et al.
Publicado: (2017)

Quantitative Ubiquitylome Analysis Reveals the Specificity of RNF111/Arkadia E3 Ubiquitin Ligase for its Degradative Substrates SKI and SKIL/SnoN in TGF-β Signaling Pathway
por: Laigle, Victor, et al.
Publicado: (2021)

Phospholipid Scramblase 1, an interferon-regulated gene located at 3q23, is regulated by SnoN/SkiL in ovarian cancer cells
por: Kodigepalli, Karthik M, et al.
Publicado: (2013)

SnoN Facilitates Axonal Regeneration after Spinal Cord Injury
por: Do, Jiun L., et al.
Publicado: (2013)

Molecular mechanism of smurf2 in regulating the expression of SnoN in diabetic nephropathy
por: Xu, Zhuojia, et al.
Publicado: (2017)

SnoN expression is differently regulated in microsatellite unstable compared with microsatellite stable colorectal cancers
por: Chia, June A, et al.
Publicado: (2006)

BMP-7 ameliorates partial epithelial-mesenchymal transition by restoring SnoN protein level via Smad1/5 pathway in diabetic kidney disease
por: Peng, Wei, et al.
Publicado: (2022)

The Crystal Structure of the Dachshund Domain of Human SnoN Reveals Flexibility in the Putative Protein Interaction Surface
por: Nyman, Tomas, et al.
Publicado: (2010)

The Proteasome Inhibitor, MG132, Attenuates Diabetic Nephropathy by Inhibiting SnoN Degradation In Vivo and In Vitro
por: Huang, Wei, et al.
Publicado: (2014)

The influence of SnoN gene silencing by siRNA on the cell proliferation and apoptosis of human pancreatic cancer cells
por: Liu, Chengli, et al.
Publicado: (2015)

Expression Profiles of SnoN in Normal and Cancerous Human Tissues Support Its Tumor Suppressor Role in Human Cancer
por: Jahchan, Nadine S., et al.
Publicado: (2013)

Sumoylated SnoN interacts with HDAC1 and p300/CBP to regulate EMT-associated phenotypes in mammary organoids
por: Chanda, Ayan, et al.
Publicado: (2023)

Transforming growth factor β(1 )inhibits bone morphogenic protein (BMP)-2 and BMP-7 signaling via upregulation of Ski-related novel protein N (SnoN): possible mechanism for the failure of BMP therapy?
por: Ehnert, Sabrina, et al.
Publicado: (2012)

BMP-7 enhances SnoN mRNA expression in renal tubular epithelial cells under high-glucose conditions
por: Wang, Yuanyuan, et al.
Publicado: (2017)

The Drosophila functional Smad suppressing element fuss, a homologue of the human Skor genes, retains pro-oncogenic properties of the Ski/Sno family
por: Rass, Mathias, et al.
Publicado: (2022)

Nuclear Respiratory Factor-1, a Novel SMAD4 Binding Protein, Represses TGF-β/SMAD4 Signaling by Functioning as a Transcriptional Cofactor
por: Rajasekaran, Nirmal, et al.
Publicado: (2021)

Mutations in SKI in Shprintzen–Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization
por: Gori, Ilaria, et al.
Publicado: (2021)

Inhibition of FGF and TGF-β Pathways in hESCs Identify STOX2 as a Novel SMAD2/4 Cofactor
por: Renz, Peter F., et al.
Publicado: (2020)

The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer
por: Gibbs, Zane A, et al.
Publicado: (2020)

Releasing Ski-Smad4 mediated suppression is essential to license Th17 differentiation
por: Zhang, Song, et al.
Publicado: (2017)

To Ski or Not to Ski on Replaced Hips
por: Wilson, Michael
Publicado: (1990)

The physics of skiing: skiing at the triple point
por: Lind, David A, et al.
Publicado: (2004)

Skiing Injuries at the Dizin Ski Resort
por: Khalilifar, Amir Hossein, et al.
Publicado: (2012)

Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in T(H)17 differentiation
por: Yoon, Jeong-Hwan, et al.
Publicado: (2015)

Identification of genes modulated by interferon gamma in breast cancer cells
por: Tecalco-Cruz, Angeles C., et al.
Publicado: (2021)

Skiing
por: ATLAS Collaboration
Publicado: (2015)

Ski
Publicado: (1965)

Ski
Publicado: (1965)

Decoding the Therapeutic Implications of the ERα Stability and Subcellular Distribution in Breast Cancer
por: Tecalco-Cruz, Angeles C., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_j9ivkg4bc0i3fhq54lpjhnhj34