Inflammation, neurodegeneration and protein aggregation in the retina as ocular biomarkers for Alzheimer’s disease in the 3xTg-AD mouse model

Alzheimer's disease (AD) is the most common cause of dementia in the elderly. In the pathogenesis of AD a pivotal role is played by two neurotoxic proteins that aggregate and accumulate in the central nervous system: amyloid beta and hyper-phosphorylated tau. Accumulation of extracellular amylo...

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Detalles Bibliográficos
Autores principales: Grimaldi, Alfonso, Brighi, Carlo, Peruzzi, Giovanna, Ragozzino, Davide, Bonanni, Valentina, Limatola, Cristina, Ruocco, Giancarlo, Di Angelantonio, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992214/
https://www.ncbi.nlm.nih.gov/pubmed/29880901
http://dx.doi.org/10.1038/s41419-018-0740-5

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