HuR regulates telomerase activity through TERC methylation

Telomerase consists of the catalytic protein TERT and the RNA TERC. Mutations in TERC are linked to human diseases, but the underlying mechanisms are poorly understood. Here we report that the RNA-binding protein HuR associates with TERC and promotes the assembly of the TERC/TERT complex by facilita...

Descripción completa

Detalles Bibliográficos
Autores principales: Tang, Hao, Wang, Hu, Cheng, Xiaolei, Fan, Xiuqin, Yang, Fan, Zhang, Mengmeng, Chen, Yanlian, Tian, Yuyang, Liu, Cihang, Shao, Dongxing, Jiang, Bin, Dou, Yali, Cong, Yusheng, Xing, Junyue, Zhang, Xiaotian, Yi, Xia, Songyang, Zhou, Ma, Wenbin, Zhao, Yong, Wang, Xian, Ma, Jinbiao, Gorospe, Myriam, Ju, Zhenyu, Wang, Wengong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992219/
https://www.ncbi.nlm.nih.gov/pubmed/29880812
http://dx.doi.org/10.1038/s41467-018-04617-7

Ejemplares similares

Ejemplares similares