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Binding, Thermodynamics, and Selectivity of a Non-peptide Antagonist to the Melanocortin-4 Receptor

The melanocortin-4 receptor (MC4R) is a potential drug target for treatment of obesity, anxiety, depression, and sexual dysfunction. Crystal structures for MC4R are not yet available, which has hindered successful structure-based drug design. Using microsecond-scale molecular-dynamics simulations, w...

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Detalles Bibliográficos
Autores principales:	Saleh, Noureldin, Kleinau, Gunnar, Heyder, Nicolas, Clark, Timothy, Hildebrand, Peter W., Scheerer, Patrick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992272/ https://www.ncbi.nlm.nih.gov/pubmed/29910730 http://dx.doi.org/10.3389/fphar.2018.00560

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