Cargando…

Vitamin D3 supplementation in obese, African-American, vitamin D deficient adolescents

OBJECTIVES: Obese, African-American (AA) adolescents are at increased risk for vitamin D deficiency. The primary objective of this pilot study was to examine the effect of vitamin D supplementation upon 25-hydroxy vitamin D (25OHD) levels in obese, AA adolescents. METHODS: A randomized, double-blind...

Descripción completa

Detalles Bibliográficos
Autores principales: Magge, Sheela N., Prasad, Divya, Zemel, Babette S., Kelly, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992315/
https://www.ncbi.nlm.nih.gov/pubmed/29892560
http://dx.doi.org/10.1016/j.jcte.2018.03.001
_version_ 1783329996557778944
author Magge, Sheela N.
Prasad, Divya
Zemel, Babette S.
Kelly, Andrea
author_facet Magge, Sheela N.
Prasad, Divya
Zemel, Babette S.
Kelly, Andrea
author_sort Magge, Sheela N.
collection PubMed
description OBJECTIVES: Obese, African-American (AA) adolescents are at increased risk for vitamin D deficiency. The primary objective of this pilot study was to examine the effect of vitamin D supplementation upon 25-hydroxy vitamin D (25OHD) levels in obese, AA adolescents. METHODS: A randomized, double-blinded, controlled pilot study included 26 obese (BMI ≥ 95%ile), vitamin D deficient (25OHD < 20 ng/mL), pubertal AA adolescents (ages 12–17). Subjects received cholecalciferol 1000 IU or 5000 IU daily for 3 months. Serum 25OHD, vitamin D binding protein, parathyroid hormone, and cardiometabolic risk markers were obtained at baseline and post-treatment. RESULTS: Of 39 subjects enrolled, 26 (67%) were vitamin D deficient (mean 25OHD 12.0 ± 3.8 ng/mL) at baseline and were randomized, with 22 completing the study. Sex, age, season, pubertal stage, BMI, insulin resistance (HOMA-IR) and 25OHD were similar at baseline between the 1000 IU and 5000 IU groups. Post-treatment, 25OHD increased less in the 1000 IU group (5.6 ng/mL, p = 0.03) vs. the 5000 IU group (15.6 ng/mL, p = 0.002). 83% of the 5000 IU group and 30% of the 1000 IU group reached post-treatment 25OHD ≥ 20 ng/mL (p = 0.01); 50% of the 5000 IU group, but no subject from the 1000 IU group, achieved 25OHD ≥ 30 ng/mL (p = 0.009). We detected no group differences in mineral metabolites or cardiometabolic risk markers following supplementation. CONCLUSIONS: Cholecalciferol dosing in excess of the current Institute of Medicine dietary reference intakes was required to achieve 25OHD levels ≥20 ng/mL in obese, AA adolescents. Supplementation of 5000 IU may be required to achieve the desired goal.
format Online
Article
Text
id pubmed-5992315
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-59923152018-06-11 Vitamin D3 supplementation in obese, African-American, vitamin D deficient adolescents Magge, Sheela N. Prasad, Divya Zemel, Babette S. Kelly, Andrea J Clin Transl Endocrinol Research Paper OBJECTIVES: Obese, African-American (AA) adolescents are at increased risk for vitamin D deficiency. The primary objective of this pilot study was to examine the effect of vitamin D supplementation upon 25-hydroxy vitamin D (25OHD) levels in obese, AA adolescents. METHODS: A randomized, double-blinded, controlled pilot study included 26 obese (BMI ≥ 95%ile), vitamin D deficient (25OHD < 20 ng/mL), pubertal AA adolescents (ages 12–17). Subjects received cholecalciferol 1000 IU or 5000 IU daily for 3 months. Serum 25OHD, vitamin D binding protein, parathyroid hormone, and cardiometabolic risk markers were obtained at baseline and post-treatment. RESULTS: Of 39 subjects enrolled, 26 (67%) were vitamin D deficient (mean 25OHD 12.0 ± 3.8 ng/mL) at baseline and were randomized, with 22 completing the study. Sex, age, season, pubertal stage, BMI, insulin resistance (HOMA-IR) and 25OHD were similar at baseline between the 1000 IU and 5000 IU groups. Post-treatment, 25OHD increased less in the 1000 IU group (5.6 ng/mL, p = 0.03) vs. the 5000 IU group (15.6 ng/mL, p = 0.002). 83% of the 5000 IU group and 30% of the 1000 IU group reached post-treatment 25OHD ≥ 20 ng/mL (p = 0.01); 50% of the 5000 IU group, but no subject from the 1000 IU group, achieved 25OHD ≥ 30 ng/mL (p = 0.009). We detected no group differences in mineral metabolites or cardiometabolic risk markers following supplementation. CONCLUSIONS: Cholecalciferol dosing in excess of the current Institute of Medicine dietary reference intakes was required to achieve 25OHD levels ≥20 ng/mL in obese, AA adolescents. Supplementation of 5000 IU may be required to achieve the desired goal. Elsevier 2018-03-21 /pmc/articles/PMC5992315/ /pubmed/29892560 http://dx.doi.org/10.1016/j.jcte.2018.03.001 Text en © 2018 Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Paper
Magge, Sheela N.
Prasad, Divya
Zemel, Babette S.
Kelly, Andrea
Vitamin D3 supplementation in obese, African-American, vitamin D deficient adolescents
title Vitamin D3 supplementation in obese, African-American, vitamin D deficient adolescents
title_full Vitamin D3 supplementation in obese, African-American, vitamin D deficient adolescents
title_fullStr Vitamin D3 supplementation in obese, African-American, vitamin D deficient adolescents
title_full_unstemmed Vitamin D3 supplementation in obese, African-American, vitamin D deficient adolescents
title_short Vitamin D3 supplementation in obese, African-American, vitamin D deficient adolescents
title_sort vitamin d3 supplementation in obese, african-american, vitamin d deficient adolescents
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992315/
https://www.ncbi.nlm.nih.gov/pubmed/29892560
http://dx.doi.org/10.1016/j.jcte.2018.03.001
work_keys_str_mv AT maggesheelan vitamind3supplementationinobeseafricanamericanvitaminddeficientadolescents
AT prasaddivya vitamind3supplementationinobeseafricanamericanvitaminddeficientadolescents
AT zemelbabettes vitamind3supplementationinobeseafricanamericanvitaminddeficientadolescents
AT kellyandrea vitamind3supplementationinobeseafricanamericanvitaminddeficientadolescents