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Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design

Therapeutics based on small interfering RNA (siRNA) have promising potential as antiviral and anti-inflammatory agents. To deliver siRNA across cell membranes to reach the RNAi pathway in the cytosol of target cells, non-viral nanoparticulate delivery approaches are explored. Recently, we showed tha...

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Detalles Bibliográficos
Autores principales:	de Groot, Anne Marit, Thanki, Kaushik, Gangloff, Monique, Falkenberg, Emily, Zeng, Xianghui, van Bijnen, Djai C.J., van Eden, Willem, Franzyk, Henrik, Nielsen, Hanne M., Broere, Femke, Gay, Nick J., Foged, Camilla, Sijts, Alice J.A.M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992342/ https://www.ncbi.nlm.nih.gov/pubmed/29858051 http://dx.doi.org/10.1016/j.omtn.2018.02.003

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