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Liver-Targeted Anti-HBV Single-Stranded Oligonucleotides with Locked Nucleic Acid Potently Reduce HBV Gene Expression In Vivo

Chronic hepatitis B infection (CHB) is an area of high unmet medical need. Current standard-of-care therapies only rarely lead to a functional cure, defined as durable hepatitis B surface antigen (HBsAg) loss following treatment. The goal for next generation CHB therapies is to achieve a higher rate...

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Detalles Bibliográficos
Autores principales:	Javanbakht, Hassan, Mueller, Henrik, Walther, Johanna, Zhou, Xue, Lopez, Anaïs, Pattupara, Thushara, Blaising, Julie, Pedersen, Lykke, Albæk, Nanna, Jackerott, Malene, Shi, Tianlai, Ploix, Corinne, Driessen, Wouter, Persson, Robert, Ravn, Jacob, Young, John A.T., Ottosen, Søren
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992345/ https://www.ncbi.nlm.nih.gov/pubmed/29858079 http://dx.doi.org/10.1016/j.omtn.2018.02.005

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