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Metal Coated Colloidosomes as Carriers for an Antibiotic
Colloidosomes are polymer shell microcapsules. They are stable and easy to prepare and have been used to encapsulate drugs for release at specific areas in the body. Traditional polymer shell capsules cannot totally seal drugs, since they are porous, and small molecules diffuse through the polymer s...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992442/ https://www.ncbi.nlm.nih.gov/pubmed/29911102 http://dx.doi.org/10.3389/fchem.2018.00196 |
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author | Sun, Qian Zhao, Ziyan Hall, Elizabeth A. H. Routh, Alexander F. |
author_facet | Sun, Qian Zhao, Ziyan Hall, Elizabeth A. H. Routh, Alexander F. |
author_sort | Sun, Qian |
collection | PubMed |
description | Colloidosomes are polymer shell microcapsules. They are stable and easy to prepare and have been used to encapsulate drugs for release at specific areas in the body. Traditional polymer shell capsules cannot totally seal drugs, since they are porous, and small molecules diffuse through the polymer shell. In this paper, we report a method for encapsulating an antibiotic kanamycin using gold or silver coated colloidosomes. The colloidosomes are impermeable and can be triggered using ultrasound. To investigate the application of the capsules in a biological system, Escherichia Coli (E. coli) was chosen as a model organism. After triggering, the released antibiotic, as well as the metal shell fragments, kill E. coli. Both the silver and gold shells colloidosomes are toxic to this bacterial system and the gold coated colloidosomes can load a higher concentration of kanamycin. |
format | Online Article Text |
id | pubmed-5992442 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-59924422018-06-15 Metal Coated Colloidosomes as Carriers for an Antibiotic Sun, Qian Zhao, Ziyan Hall, Elizabeth A. H. Routh, Alexander F. Front Chem Chemistry Colloidosomes are polymer shell microcapsules. They are stable and easy to prepare and have been used to encapsulate drugs for release at specific areas in the body. Traditional polymer shell capsules cannot totally seal drugs, since they are porous, and small molecules diffuse through the polymer shell. In this paper, we report a method for encapsulating an antibiotic kanamycin using gold or silver coated colloidosomes. The colloidosomes are impermeable and can be triggered using ultrasound. To investigate the application of the capsules in a biological system, Escherichia Coli (E. coli) was chosen as a model organism. After triggering, the released antibiotic, as well as the metal shell fragments, kill E. coli. Both the silver and gold shells colloidosomes are toxic to this bacterial system and the gold coated colloidosomes can load a higher concentration of kanamycin. Frontiers Media S.A. 2018-06-01 /pmc/articles/PMC5992442/ /pubmed/29911102 http://dx.doi.org/10.3389/fchem.2018.00196 Text en Copyright © 2018 Sun, Zhao, Hall and Routh. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Chemistry Sun, Qian Zhao, Ziyan Hall, Elizabeth A. H. Routh, Alexander F. Metal Coated Colloidosomes as Carriers for an Antibiotic |
title | Metal Coated Colloidosomes as Carriers for an Antibiotic |
title_full | Metal Coated Colloidosomes as Carriers for an Antibiotic |
title_fullStr | Metal Coated Colloidosomes as Carriers for an Antibiotic |
title_full_unstemmed | Metal Coated Colloidosomes as Carriers for an Antibiotic |
title_short | Metal Coated Colloidosomes as Carriers for an Antibiotic |
title_sort | metal coated colloidosomes as carriers for an antibiotic |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992442/ https://www.ncbi.nlm.nih.gov/pubmed/29911102 http://dx.doi.org/10.3389/fchem.2018.00196 |
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