Novel DNA Aptamers that Bind to Mutant Huntingtin and Modify Its Activity

The CAG repeat expansion that elongates the polyglutamine tract in huntingtin is the root genetic cause of Huntington’s disease (HD), a debilitating neurodegenerative disorder. This seemingly slight change to the primary amino acid sequence alters the physical structure of the mutant protein and alt...

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Detalles Bibliográficos
Autores principales: Shin, Baehyun, Jung, Roy, Oh, Hyejin, Owens, Gwen E., Lee, Hyeongseok, Kwak, Seung, Lee, Ramee, Cotman, Susan L., Lee, Jong-Min, MacDonald, Marcy E., Song, Ji-Joon, Vijayvargia, Ravi, Seong, Ihn Sik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992459/
https://www.ncbi.nlm.nih.gov/pubmed/29858077
http://dx.doi.org/10.1016/j.omtn.2018.03.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992459/
https://www.ncbi.nlm.nih.gov/pubmed/29858077
http://dx.doi.org/10.1016/j.omtn.2018.03.008

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