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Antibody-Antisense Oligonucleotide Conjugate Downregulates a Key Gene in Glioblastoma Stem Cells

Glioblastoma stem cells (GSCs) are invasive, treatment-resistant brain cancer cells that express downregulated in renal cell carcinoma (DRR), also called FAM107A, a genetic driver of GSC invasion. We developed antibody-antisense oligonucleotide (AON) conjugates to target and reduce DRR/FAM107A expre...

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Detalles Bibliográficos
Autores principales:	Arnold, Amy E., Malek-Adamian, Elise, Le, Phuong U., Meng, Anika, Martínez-Montero, Saúl, Petrecca, Kevin, Damha, Masad J., Shoichet, Molly S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992475/ https://www.ncbi.nlm.nih.gov/pubmed/29858087 http://dx.doi.org/10.1016/j.omtn.2018.04.004

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