miR-199a-3p Modulates MTOR and PAK4 Pathways and Inhibits Tumor Growth in a Hepatocellular Carcinoma Transgenic Mouse Model

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. Prognosis is poor, and therapeutic options are limited. MicroRNAs (miRNAs) have emerged as potential therapeutic molecules against cancer. Here, we investigated the therapeutic efficacy of miR-199a-3p, an m...

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Detalles Bibliográficos
Autores principales: Callegari, Elisa, D’Abundo, Lucilla, Guerriero, Paola, Simioni, Carolina, Elamin, Bahaeldin K., Russo, Marta, Cani, Alice, Bassi, Cristian, Zagatti, Barbara, Giacomelli, Luciano, Blandamura, Stella, Moshiri, Farzaneh, Ultimo, Simona, Frassoldati, Antonio, Altavilla, Giuseppe, Gramantieri, Laura, Neri, Luca Maria, Sabbioni, Silvia, Negrini, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992479/
https://www.ncbi.nlm.nih.gov/pubmed/29858083
http://dx.doi.org/10.1016/j.omtn.2018.04.002

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